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Global fitness landscapes of the Shine-Dalgarno sequence

Shine-Dalgarno sequences (SD) in prokaryotic mRNA facilitate protein translation by pairing with rRNA in ribosomes. Although conventionally defined as AG-rich motifs, recent genomic surveys reveal great sequence diversity, questioning how SD functions. Here, we determined the molecular fitness (i.e....

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Detalles Bibliográficos
Autores principales:	Kuo, Syue-Ting, Jahn, Ruey-Lin, Cheng, Yuan-Ju, Chen, Yi-Lan, Lee, Yun-Ju, Hollfelder, Florian, Wen, Jin-Der, Chou, Hsin-Hung David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263185/ https://www.ncbi.nlm.nih.gov/pubmed/32424071 http://dx.doi.org/10.1101/gr.260182.119

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