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Recent advances in the contribution of noncoding RNAs to cisplatin resistance in cervical cancer
Cervical cancer (CC) remains a major disease burden on the female population worldwide. Chemotherapy with cisplatin (cis-diamminedichloroplatinum (II); CDDP) and related drugs are the main treatment option for CC; however, their efficacy is limited by the development of drug resistance. Noncoding RN...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
PeerJ Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263300/ https://www.ncbi.nlm.nih.gov/pubmed/32523813 http://dx.doi.org/10.7717/peerj.9234 |
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author | Wen, Xin Liu, Shui Sheng, Jiyao Cui, Manhua |
author_facet | Wen, Xin Liu, Shui Sheng, Jiyao Cui, Manhua |
author_sort | Wen, Xin |
collection | PubMed |
description | Cervical cancer (CC) remains a major disease burden on the female population worldwide. Chemotherapy with cisplatin (cis-diamminedichloroplatinum (II); CDDP) and related drugs are the main treatment option for CC; however, their efficacy is limited by the development of drug resistance. Noncoding RNAs (ncRNAs) have been found to play critical roles in numerous physiological and pathological cellular processes, including drug resistance of cancer cells. In this review, we describe some of the ncRNAs, including miRNAs, lncRNAs and circRNAs, that are involved in the sensitivity/resistance of CC to CDDP-based chemotherapy and discuss their mechanisms of action. We also describe some ncRNAs that could be therapeutic targets to improve the sensitivity of CC to CDDP-based chemotherapy. |
format | Online Article Text |
id | pubmed-7263300 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | PeerJ Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-72633002020-06-09 Recent advances in the contribution of noncoding RNAs to cisplatin resistance in cervical cancer Wen, Xin Liu, Shui Sheng, Jiyao Cui, Manhua PeerJ Gynecology and Obstetrics Cervical cancer (CC) remains a major disease burden on the female population worldwide. Chemotherapy with cisplatin (cis-diamminedichloroplatinum (II); CDDP) and related drugs are the main treatment option for CC; however, their efficacy is limited by the development of drug resistance. Noncoding RNAs (ncRNAs) have been found to play critical roles in numerous physiological and pathological cellular processes, including drug resistance of cancer cells. In this review, we describe some of the ncRNAs, including miRNAs, lncRNAs and circRNAs, that are involved in the sensitivity/resistance of CC to CDDP-based chemotherapy and discuss their mechanisms of action. We also describe some ncRNAs that could be therapeutic targets to improve the sensitivity of CC to CDDP-based chemotherapy. PeerJ Inc. 2020-05-29 /pmc/articles/PMC7263300/ /pubmed/32523813 http://dx.doi.org/10.7717/peerj.9234 Text en © 2020 Wen et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited. |
spellingShingle | Gynecology and Obstetrics Wen, Xin Liu, Shui Sheng, Jiyao Cui, Manhua Recent advances in the contribution of noncoding RNAs to cisplatin resistance in cervical cancer |
title | Recent advances in the contribution of noncoding RNAs to cisplatin resistance in cervical cancer |
title_full | Recent advances in the contribution of noncoding RNAs to cisplatin resistance in cervical cancer |
title_fullStr | Recent advances in the contribution of noncoding RNAs to cisplatin resistance in cervical cancer |
title_full_unstemmed | Recent advances in the contribution of noncoding RNAs to cisplatin resistance in cervical cancer |
title_short | Recent advances in the contribution of noncoding RNAs to cisplatin resistance in cervical cancer |
title_sort | recent advances in the contribution of noncoding rnas to cisplatin resistance in cervical cancer |
topic | Gynecology and Obstetrics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263300/ https://www.ncbi.nlm.nih.gov/pubmed/32523813 http://dx.doi.org/10.7717/peerj.9234 |
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