Cargando…

Recent advances in the contribution of noncoding RNAs to cisplatin resistance in cervical cancer

Cervical cancer (CC) remains a major disease burden on the female population worldwide. Chemotherapy with cisplatin (cis-diamminedichloroplatinum (II); CDDP) and related drugs are the main treatment option for CC; however, their efficacy is limited by the development of drug resistance. Noncoding RN...

Descripción completa

Detalles Bibliográficos
Autores principales: Wen, Xin, Liu, Shui, Sheng, Jiyao, Cui, Manhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263300/
https://www.ncbi.nlm.nih.gov/pubmed/32523813
http://dx.doi.org/10.7717/peerj.9234
_version_ 1783540783307030528
author Wen, Xin
Liu, Shui
Sheng, Jiyao
Cui, Manhua
author_facet Wen, Xin
Liu, Shui
Sheng, Jiyao
Cui, Manhua
author_sort Wen, Xin
collection PubMed
description Cervical cancer (CC) remains a major disease burden on the female population worldwide. Chemotherapy with cisplatin (cis-diamminedichloroplatinum (II); CDDP) and related drugs are the main treatment option for CC; however, their efficacy is limited by the development of drug resistance. Noncoding RNAs (ncRNAs) have been found to play critical roles in numerous physiological and pathological cellular processes, including drug resistance of cancer cells. In this review, we describe some of the ncRNAs, including miRNAs, lncRNAs and circRNAs, that are involved in the sensitivity/resistance of CC to CDDP-based chemotherapy and discuss their mechanisms of action. We also describe some ncRNAs that could be therapeutic targets to improve the sensitivity of CC to CDDP-based chemotherapy.
format Online
Article
Text
id pubmed-7263300
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher PeerJ Inc.
record_format MEDLINE/PubMed
spelling pubmed-72633002020-06-09 Recent advances in the contribution of noncoding RNAs to cisplatin resistance in cervical cancer Wen, Xin Liu, Shui Sheng, Jiyao Cui, Manhua PeerJ Gynecology and Obstetrics Cervical cancer (CC) remains a major disease burden on the female population worldwide. Chemotherapy with cisplatin (cis-diamminedichloroplatinum (II); CDDP) and related drugs are the main treatment option for CC; however, their efficacy is limited by the development of drug resistance. Noncoding RNAs (ncRNAs) have been found to play critical roles in numerous physiological and pathological cellular processes, including drug resistance of cancer cells. In this review, we describe some of the ncRNAs, including miRNAs, lncRNAs and circRNAs, that are involved in the sensitivity/resistance of CC to CDDP-based chemotherapy and discuss their mechanisms of action. We also describe some ncRNAs that could be therapeutic targets to improve the sensitivity of CC to CDDP-based chemotherapy. PeerJ Inc. 2020-05-29 /pmc/articles/PMC7263300/ /pubmed/32523813 http://dx.doi.org/10.7717/peerj.9234 Text en © 2020 Wen et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.
spellingShingle Gynecology and Obstetrics
Wen, Xin
Liu, Shui
Sheng, Jiyao
Cui, Manhua
Recent advances in the contribution of noncoding RNAs to cisplatin resistance in cervical cancer
title Recent advances in the contribution of noncoding RNAs to cisplatin resistance in cervical cancer
title_full Recent advances in the contribution of noncoding RNAs to cisplatin resistance in cervical cancer
title_fullStr Recent advances in the contribution of noncoding RNAs to cisplatin resistance in cervical cancer
title_full_unstemmed Recent advances in the contribution of noncoding RNAs to cisplatin resistance in cervical cancer
title_short Recent advances in the contribution of noncoding RNAs to cisplatin resistance in cervical cancer
title_sort recent advances in the contribution of noncoding rnas to cisplatin resistance in cervical cancer
topic Gynecology and Obstetrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263300/
https://www.ncbi.nlm.nih.gov/pubmed/32523813
http://dx.doi.org/10.7717/peerj.9234
work_keys_str_mv AT wenxin recentadvancesinthecontributionofnoncodingrnastocisplatinresistanceincervicalcancer
AT liushui recentadvancesinthecontributionofnoncodingrnastocisplatinresistanceincervicalcancer
AT shengjiyao recentadvancesinthecontributionofnoncodingrnastocisplatinresistanceincervicalcancer
AT cuimanhua recentadvancesinthecontributionofnoncodingrnastocisplatinresistanceincervicalcancer