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Acute Hypersensitivity Pneumonitis Associated With a High Ki-67 Proliferative Index
Hypersensitivity pneumonitis (HSP) is an interstitial lung disease caused by exposure to a large range of environmental antigens. Inhaling aerosolized particles leads to a heightened immune response. HSP comes in acute, subacute, or chronic forms, all with their own potential clinical and radiograph...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263412/ https://www.ncbi.nlm.nih.gov/pubmed/32494520 http://dx.doi.org/10.7759/cureus.7905 |
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author | Nabrinsky, Edward Kamar, Amanda Mohammed Saeed, Dereen Pins, Michael Stone, Arvey |
author_facet | Nabrinsky, Edward Kamar, Amanda Mohammed Saeed, Dereen Pins, Michael Stone, Arvey |
author_sort | Nabrinsky, Edward |
collection | PubMed |
description | Hypersensitivity pneumonitis (HSP) is an interstitial lung disease caused by exposure to a large range of environmental antigens. Inhaling aerosolized particles leads to a heightened immune response. HSP comes in acute, subacute, or chronic forms, all with their own potential clinical and radiographic findings. Mycobacterium avium complex (MAC) is the most common nontuberculous mycobacteria and is known to cause HSP with certain exposures. However, although certain histologic findings can be seen with HSP, a high ki-67 proliferation index is unusual and more commonly associated with malignancy. In this report, we discuss a case of MAC that had acute HSP associated with a high ki-67 proliferative index. |
format | Online Article Text |
id | pubmed-7263412 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-72634122020-06-02 Acute Hypersensitivity Pneumonitis Associated With a High Ki-67 Proliferative Index Nabrinsky, Edward Kamar, Amanda Mohammed Saeed, Dereen Pins, Michael Stone, Arvey Cureus Pathology Hypersensitivity pneumonitis (HSP) is an interstitial lung disease caused by exposure to a large range of environmental antigens. Inhaling aerosolized particles leads to a heightened immune response. HSP comes in acute, subacute, or chronic forms, all with their own potential clinical and radiographic findings. Mycobacterium avium complex (MAC) is the most common nontuberculous mycobacteria and is known to cause HSP with certain exposures. However, although certain histologic findings can be seen with HSP, a high ki-67 proliferation index is unusual and more commonly associated with malignancy. In this report, we discuss a case of MAC that had acute HSP associated with a high ki-67 proliferative index. Cureus 2020-04-30 /pmc/articles/PMC7263412/ /pubmed/32494520 http://dx.doi.org/10.7759/cureus.7905 Text en Copyright © 2020, Nabrinsky et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Pathology Nabrinsky, Edward Kamar, Amanda Mohammed Saeed, Dereen Pins, Michael Stone, Arvey Acute Hypersensitivity Pneumonitis Associated With a High Ki-67 Proliferative Index |
title | Acute Hypersensitivity Pneumonitis Associated With a High Ki-67 Proliferative Index |
title_full | Acute Hypersensitivity Pneumonitis Associated With a High Ki-67 Proliferative Index |
title_fullStr | Acute Hypersensitivity Pneumonitis Associated With a High Ki-67 Proliferative Index |
title_full_unstemmed | Acute Hypersensitivity Pneumonitis Associated With a High Ki-67 Proliferative Index |
title_short | Acute Hypersensitivity Pneumonitis Associated With a High Ki-67 Proliferative Index |
title_sort | acute hypersensitivity pneumonitis associated with a high ki-67 proliferative index |
topic | Pathology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263412/ https://www.ncbi.nlm.nih.gov/pubmed/32494520 http://dx.doi.org/10.7759/cureus.7905 |
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