Road Traffic Noise Exposure and Filled Prescriptions for Antihypertensive Medication: A Danish Cohort Study

BACKGROUND: Epidemiological research on effects of transportation noise on incident hypertension is inconsistent. OBJECTIVES: We aimed to investigate whether residential road traffic noise increases the risk for hypertension. METHODS: In a population-based cohort of 57,053 individuals 50–64 years of...

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Autores principales: Thacher, Jesse D., Poulsen, Aslak H., Roswall, Nina, Hvidtfeldt, Ulla, Raaschou-Nielsen, Ole, Jensen, Steen Solvang, Ketzel, Matthias, Brandt, Jørgen, Overvad, Kim, Tjønneland, Anne, Münzel, Thomas, Sørensen, Mette
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Environmental Health Perspectives 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263450/
https://www.ncbi.nlm.nih.gov/pubmed/32438890
http://dx.doi.org/10.1289/EHP6273
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author Thacher, Jesse D.
Poulsen, Aslak H.
Roswall, Nina
Hvidtfeldt, Ulla
Raaschou-Nielsen, Ole
Jensen, Steen Solvang
Ketzel, Matthias
Brandt, Jørgen
Overvad, Kim
Tjønneland, Anne
Münzel, Thomas
Sørensen, Mette
author_facet Thacher, Jesse D.
Poulsen, Aslak H.
Roswall, Nina
Hvidtfeldt, Ulla
Raaschou-Nielsen, Ole
Jensen, Steen Solvang
Ketzel, Matthias
Brandt, Jørgen
Overvad, Kim
Tjønneland, Anne
Münzel, Thomas
Sørensen, Mette
author_sort Thacher, Jesse D.
collection PubMed
description BACKGROUND: Epidemiological research on effects of transportation noise on incident hypertension is inconsistent. OBJECTIVES: We aimed to investigate whether residential road traffic noise increases the risk for hypertension. METHODS: In a population-based cohort of 57,053 individuals 50–64 years of age at enrollment, we identified 21,241 individuals who fulfilled our case definition of filling [Formula: see text] prescriptions and [Formula: see text] defined daily doses of antihypertensive drugs (AHTs) within a year, during a mean follow-up time of 14.0 y. Residential addresses from 1987 to 2016 were obtained from national registers, and road traffic noise at the most exposed façade as well as the least exposed façade was modeled for all addresses. Analyses were conducted using Cox proportional hazards models. RESULTS: We found no associations between the 10-y mean exposure to road traffic noise and filled prescriptions for AHTs, with incidence rate ratios (IRRs) of 0.999 [95% confidence intervals (CI): 0.980, 1.019)] per 10-dB increase in road traffic noise at the most exposed façade and of 1.001 (95% CI: 0.977, 1.026) at the least exposed façade. Interaction analyses suggested an association with road traffic noise at the least exposed façade among subpopulations of current smokers and obese individuals. CONCLUSION: The present study does not support an association between road traffic noise and filled prescriptions for AHTs. https://doi.org/10.1289/EHP6273
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spelling pubmed-72634502020-06-04 Road Traffic Noise Exposure and Filled Prescriptions for Antihypertensive Medication: A Danish Cohort Study Thacher, Jesse D. Poulsen, Aslak H. Roswall, Nina Hvidtfeldt, Ulla Raaschou-Nielsen, Ole Jensen, Steen Solvang Ketzel, Matthias Brandt, Jørgen Overvad, Kim Tjønneland, Anne Münzel, Thomas Sørensen, Mette Environ Health Perspect Research BACKGROUND: Epidemiological research on effects of transportation noise on incident hypertension is inconsistent. OBJECTIVES: We aimed to investigate whether residential road traffic noise increases the risk for hypertension. METHODS: In a population-based cohort of 57,053 individuals 50–64 years of age at enrollment, we identified 21,241 individuals who fulfilled our case definition of filling [Formula: see text] prescriptions and [Formula: see text] defined daily doses of antihypertensive drugs (AHTs) within a year, during a mean follow-up time of 14.0 y. Residential addresses from 1987 to 2016 were obtained from national registers, and road traffic noise at the most exposed façade as well as the least exposed façade was modeled for all addresses. Analyses were conducted using Cox proportional hazards models. RESULTS: We found no associations between the 10-y mean exposure to road traffic noise and filled prescriptions for AHTs, with incidence rate ratios (IRRs) of 0.999 [95% confidence intervals (CI): 0.980, 1.019)] per 10-dB increase in road traffic noise at the most exposed façade and of 1.001 (95% CI: 0.977, 1.026) at the least exposed façade. Interaction analyses suggested an association with road traffic noise at the least exposed façade among subpopulations of current smokers and obese individuals. CONCLUSION: The present study does not support an association between road traffic noise and filled prescriptions for AHTs. https://doi.org/10.1289/EHP6273 Environmental Health Perspectives 2020-05-14 /pmc/articles/PMC7263450/ /pubmed/32438890 http://dx.doi.org/10.1289/EHP6273 Text en https://ehp.niehs.nih.gov/about-ehp/license EHP is an open-access journal published with support from the National Institute of Environmental Health Sciences, National Institutes of Health. All content is public domain unless otherwise noted.
spellingShingle Research
Thacher, Jesse D.
Poulsen, Aslak H.
Roswall, Nina
Hvidtfeldt, Ulla
Raaschou-Nielsen, Ole
Jensen, Steen Solvang
Ketzel, Matthias
Brandt, Jørgen
Overvad, Kim
Tjønneland, Anne
Münzel, Thomas
Sørensen, Mette
Road Traffic Noise Exposure and Filled Prescriptions for Antihypertensive Medication: A Danish Cohort Study
title Road Traffic Noise Exposure and Filled Prescriptions for Antihypertensive Medication: A Danish Cohort Study
title_full Road Traffic Noise Exposure and Filled Prescriptions for Antihypertensive Medication: A Danish Cohort Study
title_fullStr Road Traffic Noise Exposure and Filled Prescriptions for Antihypertensive Medication: A Danish Cohort Study
title_full_unstemmed Road Traffic Noise Exposure and Filled Prescriptions for Antihypertensive Medication: A Danish Cohort Study
title_short Road Traffic Noise Exposure and Filled Prescriptions for Antihypertensive Medication: A Danish Cohort Study
title_sort road traffic noise exposure and filled prescriptions for antihypertensive medication: a danish cohort study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263450/
https://www.ncbi.nlm.nih.gov/pubmed/32438890
http://dx.doi.org/10.1289/EHP6273
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