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Klotho as a potential predictor of deceased donor kidney transplantation outcomes

PURPOSE: Klotho is an antiaging factor mainly produced by renal tubular cells. Klotho is reportedly decreased in an animal model of acute kidney injury and patients with chronic kidney disease. However, information on Klotho expression after kidney transplantation is limited. We analyzed the correla...

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Autores principales: Kim, Suh Min, Han, Ahram, Ahn, Sanghyun, Min, Sang-Il, Min, Seung-Kee, Ha, Jongwon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Surgical Society 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263887/
https://www.ncbi.nlm.nih.gov/pubmed/32528913
http://dx.doi.org/10.4174/astr.2020.98.6.332
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author Kim, Suh Min
Han, Ahram
Ahn, Sanghyun
Min, Sang-Il
Min, Seung-Kee
Ha, Jongwon
author_facet Kim, Suh Min
Han, Ahram
Ahn, Sanghyun
Min, Sang-Il
Min, Seung-Kee
Ha, Jongwon
author_sort Kim, Suh Min
collection PubMed
description PURPOSE: Klotho is an antiaging factor mainly produced by renal tubular cells. Klotho is reportedly decreased in an animal model of acute kidney injury and patients with chronic kidney disease. However, information on Klotho expression after kidney transplantation is limited. We analyzed the correlation between donor Klotho expression and clinical outcomes of kidney transplantation. METHODS: Sixty patients who underwent deceased donor kidney transplantation between March 2015 and October 2017 were enrolled. Serum and tissue Klotho expression levels were measured by enzyme-linked immunosorbent assay and immunohistochemistry, respectively. Graft function was assessed by estimated glomerular filtration rate (eGFR). RESULTS: Patients were divided into 2 groups according to donor Klotho expression in renal tissues. A greater improvement in eGFR was observed at 1 week after transplantation in patients receiving kidneys with higher Klotho expression (47.5 ± 21.9 mL/min/1.73 m(2) vs. 63.9 ± 28.2 mL/min/1.73 m(2), P = 0.030). Patients were also classified into 2 groups according to donor serum Klotho level. There was a tendency for a higher eGFR at 12 months after transplantation in patients receiving kidneys from donors with a higher Klotho level (51.0 ± 18.0 mL/min/1.73 m(2) vs. 61.2 ± 16.5 mL/min/1.73 m(2), P = 0.059). When subgrouped into patients with or without biopsy-proven acute rejection, 12-month eGFR remained higher in patients receiving kidneys from donors with higher serum Klotho. CONCLUSION: Our data demonstrated that donor tissue expression of Klotho correlated with early recovery of eGFR after kidney transplantation. Donor serum Klotho level tended to be associated with posttransplant 12-month eGFR. Donor Klotho expression might be a new predictor for deceased donor kidney transplantation outcome.
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spelling pubmed-72638872020-06-10 Klotho as a potential predictor of deceased donor kidney transplantation outcomes Kim, Suh Min Han, Ahram Ahn, Sanghyun Min, Sang-Il Min, Seung-Kee Ha, Jongwon Ann Surg Treat Res Original Article PURPOSE: Klotho is an antiaging factor mainly produced by renal tubular cells. Klotho is reportedly decreased in an animal model of acute kidney injury and patients with chronic kidney disease. However, information on Klotho expression after kidney transplantation is limited. We analyzed the correlation between donor Klotho expression and clinical outcomes of kidney transplantation. METHODS: Sixty patients who underwent deceased donor kidney transplantation between March 2015 and October 2017 were enrolled. Serum and tissue Klotho expression levels were measured by enzyme-linked immunosorbent assay and immunohistochemistry, respectively. Graft function was assessed by estimated glomerular filtration rate (eGFR). RESULTS: Patients were divided into 2 groups according to donor Klotho expression in renal tissues. A greater improvement in eGFR was observed at 1 week after transplantation in patients receiving kidneys with higher Klotho expression (47.5 ± 21.9 mL/min/1.73 m(2) vs. 63.9 ± 28.2 mL/min/1.73 m(2), P = 0.030). Patients were also classified into 2 groups according to donor serum Klotho level. There was a tendency for a higher eGFR at 12 months after transplantation in patients receiving kidneys from donors with a higher Klotho level (51.0 ± 18.0 mL/min/1.73 m(2) vs. 61.2 ± 16.5 mL/min/1.73 m(2), P = 0.059). When subgrouped into patients with or without biopsy-proven acute rejection, 12-month eGFR remained higher in patients receiving kidneys from donors with higher serum Klotho. CONCLUSION: Our data demonstrated that donor tissue expression of Klotho correlated with early recovery of eGFR after kidney transplantation. Donor serum Klotho level tended to be associated with posttransplant 12-month eGFR. Donor Klotho expression might be a new predictor for deceased donor kidney transplantation outcome. The Korean Surgical Society 2020-06 2020-05-28 /pmc/articles/PMC7263887/ /pubmed/32528913 http://dx.doi.org/10.4174/astr.2020.98.6.332 Text en Copyright © 2020, the Korean Surgical Society http://creativecommons.org/licenses/by-nc/4.0/ Annals of Surgical Treatment and Research is an Open Access Journal. All articles are distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Suh Min
Han, Ahram
Ahn, Sanghyun
Min, Sang-Il
Min, Seung-Kee
Ha, Jongwon
Klotho as a potential predictor of deceased donor kidney transplantation outcomes
title Klotho as a potential predictor of deceased donor kidney transplantation outcomes
title_full Klotho as a potential predictor of deceased donor kidney transplantation outcomes
title_fullStr Klotho as a potential predictor of deceased donor kidney transplantation outcomes
title_full_unstemmed Klotho as a potential predictor of deceased donor kidney transplantation outcomes
title_short Klotho as a potential predictor of deceased donor kidney transplantation outcomes
title_sort klotho as a potential predictor of deceased donor kidney transplantation outcomes
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263887/
https://www.ncbi.nlm.nih.gov/pubmed/32528913
http://dx.doi.org/10.4174/astr.2020.98.6.332
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