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Astrocyte lesions in cerebral cortex and cerebellum of dogs with congenital ortosystemic shunting

BACKGROUND: Congenital portosystemic shunt (cPSS) is one of the most common congenital disorders diagnosed in dogs. Hepatic encephalopathy (HE) is a frequent complication in dogs with a cPSS and is a major cause of morbidity and mortality. Despite HE been a major cause of morbidity in dogs with a cP...

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Autores principales: Williams, Alun, Gow, Adam, Kilpatrick, Scott, Tivers, Mickey, Lipscomb, Vicky, Smith, Ken, Day, Michael Oliver, Jeffery, Nick, Mellanby, Richard John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Veterinary Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263922/
https://www.ncbi.nlm.nih.gov/pubmed/32476318
http://dx.doi.org/10.4142/jvs.2020.21.e44
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author Williams, Alun
Gow, Adam
Kilpatrick, Scott
Tivers, Mickey
Lipscomb, Vicky
Smith, Ken
Day, Michael Oliver
Jeffery, Nick
Mellanby, Richard John
author_facet Williams, Alun
Gow, Adam
Kilpatrick, Scott
Tivers, Mickey
Lipscomb, Vicky
Smith, Ken
Day, Michael Oliver
Jeffery, Nick
Mellanby, Richard John
author_sort Williams, Alun
collection PubMed
description BACKGROUND: Congenital portosystemic shunt (cPSS) is one of the most common congenital disorders diagnosed in dogs. Hepatic encephalopathy (HE) is a frequent complication in dogs with a cPSS and is a major cause of morbidity and mortality. Despite HE been a major cause of morbidity in dogs with a cPSS, little is known about the cellular changes that occur in the central nervous system of dogs with a cPSS. OBJECTIVES: The objective of this study was to characterise the histological changes in the cerebral cortex and cerebellum of dogs with cPSS with particular emphasis on astrocyte morphology. METHODS: Eight dogs with a confirmed cPSS were included in the study. RESULTS: Six dogs had substantial numbers of Alzheimer type II astrocytes and all cases had increased immunoreactivity for glial fibrillary acidic protein in the cerebral cortex, even if there were minimal other morphological changes. CONCLUSIONS: This study demonstrates that dogs with a cPSS have marked cellular changes in the cerebral cortex and cerebellum. The cellular changes that occur in the cerebral cortex and cerebellum of dogs with spontaneously arising HE are similar to changes which occur in humans with HE, further validating dogs with a cPSS as a good model for human HE.
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spelling pubmed-72639222020-06-10 Astrocyte lesions in cerebral cortex and cerebellum of dogs with congenital ortosystemic shunting Williams, Alun Gow, Adam Kilpatrick, Scott Tivers, Mickey Lipscomb, Vicky Smith, Ken Day, Michael Oliver Jeffery, Nick Mellanby, Richard John J Vet Sci Original Article BACKGROUND: Congenital portosystemic shunt (cPSS) is one of the most common congenital disorders diagnosed in dogs. Hepatic encephalopathy (HE) is a frequent complication in dogs with a cPSS and is a major cause of morbidity and mortality. Despite HE been a major cause of morbidity in dogs with a cPSS, little is known about the cellular changes that occur in the central nervous system of dogs with a cPSS. OBJECTIVES: The objective of this study was to characterise the histological changes in the cerebral cortex and cerebellum of dogs with cPSS with particular emphasis on astrocyte morphology. METHODS: Eight dogs with a confirmed cPSS were included in the study. RESULTS: Six dogs had substantial numbers of Alzheimer type II astrocytes and all cases had increased immunoreactivity for glial fibrillary acidic protein in the cerebral cortex, even if there were minimal other morphological changes. CONCLUSIONS: This study demonstrates that dogs with a cPSS have marked cellular changes in the cerebral cortex and cerebellum. The cellular changes that occur in the cerebral cortex and cerebellum of dogs with spontaneously arising HE are similar to changes which occur in humans with HE, further validating dogs with a cPSS as a good model for human HE. The Korean Society of Veterinary Science 2020-05 2020-04-23 /pmc/articles/PMC7263922/ /pubmed/32476318 http://dx.doi.org/10.4142/jvs.2020.21.e44 Text en © 2020 The Korean Society of Veterinary Science https://creativecommons.org/licenses/by-nc/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Williams, Alun
Gow, Adam
Kilpatrick, Scott
Tivers, Mickey
Lipscomb, Vicky
Smith, Ken
Day, Michael Oliver
Jeffery, Nick
Mellanby, Richard John
Astrocyte lesions in cerebral cortex and cerebellum of dogs with congenital ortosystemic shunting
title Astrocyte lesions in cerebral cortex and cerebellum of dogs with congenital ortosystemic shunting
title_full Astrocyte lesions in cerebral cortex and cerebellum of dogs with congenital ortosystemic shunting
title_fullStr Astrocyte lesions in cerebral cortex and cerebellum of dogs with congenital ortosystemic shunting
title_full_unstemmed Astrocyte lesions in cerebral cortex and cerebellum of dogs with congenital ortosystemic shunting
title_short Astrocyte lesions in cerebral cortex and cerebellum of dogs with congenital ortosystemic shunting
title_sort astrocyte lesions in cerebral cortex and cerebellum of dogs with congenital ortosystemic shunting
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263922/
https://www.ncbi.nlm.nih.gov/pubmed/32476318
http://dx.doi.org/10.4142/jvs.2020.21.e44
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