Application of poxvirus K3 ortholog as a positive selection marker for constructing recombinant vaccinia viruses with modified host range

Vaccinia virus is capable of replicating in a wide range of vertebrate animal cells. However, deletion of the two virus host range genes, E3L and K3L, would render replication of the virus abortive in all the cell types tested, except the cells with defective PKR and RNase L activity. By expressing...

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Detalles Bibliográficos
Autores principales: Cao, Jingxin, Layne, Christine, Varga, Jessie, Deschambault, Yvon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Immunology and Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264055/
https://www.ncbi.nlm.nih.gov/pubmed/32509537
http://dx.doi.org/10.1016/j.mex.2020.100918

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264055/
https://www.ncbi.nlm.nih.gov/pubmed/32509537
http://dx.doi.org/10.1016/j.mex.2020.100918

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