Cargando…

Overexpression of FAM46A, a Non-canonical Poly(A) Polymerase, Promotes Hemin-Induced Hemoglobinization in K562 Cells

FAM46A belongs to the FAM46 subfamily of the nucleotidyltransferase-fold superfamily and is predicted to be a non-canonical poly(A) polymerase. FAM46A has been linked to several human disorders including retinitis pigmentosa, bone abnormality, cancer, and obesity. However, its molecular and function...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lin, Hsi-Hsien, Lo, Yu-Ling, Wang, Wen-Chih, Huang, Kuan-Yeh, I, Kuan-Yu, Chang, Gin-Wen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264091/ https://www.ncbi.nlm.nih.gov/pubmed/32528962 http://dx.doi.org/10.3389/fcell.2020.00414

Ejemplares similares

FAM46 proteins are novel eukaryotic non-canonical poly(A) polymerases
por: Kuchta, Krzysztof, et al.
Publicado: (2016)

The non-canonical poly(A) polymerase FAM46C acts as an onco-suppressor in multiple myeloma
por: Mroczek, Seweryn, et al.
Publicado: (2017)

Structural and functional characterization of multiple myeloma associated cytoplasmic poly(A) polymerase FAM46C
por: Zhang, Hong, et al.
Publicado: (2021)

FAM46B is a prokaryotic-like cytoplasmic poly(A) polymerase essential in human embryonic stem cells
por: Hu, Jia-Li, et al.
Publicado: (2020)

New Insights into Hemopexin-Binding to Hemin and Hemoglobin
por: Lechuga, Guilherme C., et al.
Publicado: (2022)

Voltage-Gated K(+) Channel, K(v)3.3 Is Involved in Hemin-Induced K562 Differentiation
por: Song, Min Seok, et al.
Publicado: (2016)

Glutathione–Hemin/Hematin Adduct Formation to Disintegrate Cytotoxic Oxidant Hemin/Hematin in Human K562 Cells and Red Blood Cells’ Hemolysates: Impact of Glutathione on the Hemolytic Disorders and Homeostasis
por: Georgiou-Siafis, Sofia K., et al.
Publicado: (2022)

Hemin Augments Growth and Hemoglobinization of Erythroid Precursors from Patients with Diamond-Blackfan Anemia
por: Fibach, Eitan, et al.
Publicado: (2012)

Endogenous hepcidin synthesis protects the distal nephron against hemin and hemoglobin mediated necroptosis
por: van Swelm, Rachel P. L., et al.
Publicado: (2018)

Distinct Roles of Non-Canonical Poly(A) Polymerases in RNA Metabolism
por: Paolo, Salvatore San, et al.
Publicado: (2009)

The potential functions of FAM46C in oral squamous cell carcinoma
por: Zhuang, Xiaohua, et al.
Publicado: (2018)

Dataset on characterization of hemin-azide derivative and DNA oligonucleotide-hemin conjugate
por: Kosman, J., et al.
Publicado: (2017)

Association of Variable Number of Tandem Repeats in the Coding Region of the FAM46A Gene, FAM46A rs11040 SNP and BAG6 rs3117582 SNP with Susceptibility to Tuberculosis
por: Etokebe, Godfrey Essien, et al.
Publicado: (2014)

Bioinspired Electropun Fibrous Materials Based on Poly-3-Hydroxybutyrate and Hemin: Preparation, Physicochemical Properties, and Weathering
por: Tyubaeva, Polina M., et al.
Publicado: (2022)

Poly(A) polymerase (PAP) diversity in gene expression – Star-PAP vs canonical PAP
por: Laishram, Rakesh S.
Publicado: (2014)

Mechanistic insights into RNA surveillance by the canonical poly(A) polymerase Pla1 of the MTREC complex
por: Soni, Komal, et al.
Publicado: (2023)

Visual detection of Fusarium proliferatum based on asymmetric recombinase polymerase amplification and hemin/G-quadruplex DNAzyme
por: Wang, Ying, et al.
Publicado: (2019)

The Activation and Signaling Mechanisms of GPR56/ADGRG1 in Melanoma Cell
por: Huang, Kuan-Yeh, et al.
Publicado: (2018)

PDIP46 (DNA polymerase δ interacting protein 46) is an activating factor for human DNA polymerase δ
por: Wang, Xiaoxiao, et al.
Publicado: (2016)

Canonical Poly(A) Polymerase Activity Promotes the Decay of a Wide Variety of Mammalian Nuclear RNAs
por: Bresson, Stefan M., et al.
Publicado: (2015)

Essential role for non-canonical poly(A) polymerase GLD4 in cytoplasmic polyadenylation and carbohydrate metabolism
por: Shin, Jihae, et al.
Publicado: (2017)

The Porphyromonas gingivalis Ferric Uptake Regulator Orthologue Binds Hemin and Regulates Hemin-Responsive Biofilm Development
por: Butler, Catherine A., et al.
Publicado: (2014)

FAM46C as a Potential Marker for Pan-Cancer Prognosis and Predicting Immunotherapeutic Efficacy
por: Deng, Jiehua, et al.
Publicado: (2022)

Inhibition of FAM46/TENT5 activity by BCCIPα adopting a unique fold
por: Liu, Shun, et al.
Publicado: (2023)

FAM46C Is an Interferon-Stimulated Gene That Inhibits Lentiviral Particle Production by Modulating Autophagy
por: Mancino, Marilena, et al.
Publicado: (2023)

Effect of the Hemin Molecular Complexes on the Structure and Properties of the Composite Electrospun Materials Based on Poly(3-hydroxybutyrate)
por: Tyubaeva, Polina, et al.
Publicado: (2021)

Comparison of Characteristics and DNAzyme Activity of G4–Hemin Conjugates Obtained via Two Hemin Attachment Methods
por: Kosman, Joanna, et al.
Publicado: (2018)

FAM83F regulates canonical Wnt signalling through an interaction with CK1α
por: Dunbar, Karen, et al.
Publicado: (2020)

Activation of Adhesion GPCR EMR2/ADGRE2 Induces Macrophage Differentiation and Inflammatory Responses via Gα(16)/Akt/MAPK/NF-κB Signaling Pathways
por: I, Kuan-Yu, et al.
Publicado: (2017)

Immunoglobulin expression and the humoral immune response is regulated by the non-canonical poly(A) polymerase TENT5C
por: Bilska, Aleksandra, et al.
Publicado: (2020)

FAM46C is critical for the anti-proliferation and pro-apoptotic effects of norcantharidin in hepatocellular carcinoma cells
por: Zhang, Qiao-Yan, et al.
Publicado: (2017)

FAM46C-mediated tumor heterogeneity predicts extramedullary metastasis and poorer survival in multiple myeloma
por: Zhang, Weilong, et al.
Publicado: (2023)

A Genetic Variant of FAM46A is Associated With the Development of Adolescent Idiopathic Scoliosis in the Chinese Population
por: Min, Kaixing, et al.
Publicado: (2023)

Overexpression of FAM83A Is Associated with Poor Prognosis of Lung Adenocarcinoma
por: Liu, Xin, et al.
Publicado: (2022)

Hemin–G-quadruplex-crosslinked poly-N-isopropylacrylamide hydrogel: a catalytic matrix for the deposition of conductive polyaniline
por: Lu, Chun-Hua, et al.
Publicado: (2015)

FAM20A binds to and regulates FAM20C localization
por: Ohyama, Yoshio, et al.
Publicado: (2016)

Development and characterization of K562 cell clones expressing BCL11A-XL: Decreased hemoglobin production with fetal hemoglobin inducers and its rescue with mithramycin
por: Finotti, Alessia, et al.
Publicado: (2015)

Proteomic analysis of the effect of hemin in breast cancer
por: Coló, G. P., et al.
Publicado: (2023)

FAM46B Promotes Apoptosis and Inhibits Glycolysis of Prostate Cancer Through Inhibition of the MYC-LDHA Axis
por: Liang, Tao, et al.
Publicado: (2020)

Poly(ADP-ribose) polymerase-3 overexpression is associated with poor prognosis in patients with breast cancer following chemotherapy
por: Song, Zhiguo, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_cfu5kobhbj6iijhgmt57s18tvp