Effect of congenital adrenal hyperplasia treated by glucocorticoids on plasma metabolome: a machine-learning-based analysis

Background. Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency leads to impaired cortisol biosynthesis. Treatment includes glucocorticoid supplementation. We studied the specific metabolomics signatures in CAH patients using two different algorithms. Methods. In a case-control stu...

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Detalles Bibliográficos
Autores principales: Nguyen, Lee S., Prifti, Edi, Ichou, Farid, Leban, Monique, Funck-Brentano, Christian, Touraine, Philippe, Salem, Joe-Elie, Bachelot, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264133/
https://www.ncbi.nlm.nih.gov/pubmed/32483270
http://dx.doi.org/10.1038/s41598-020-65897-y

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