Chronic expression of p16(INK4a) in the epidermis induces Wnt-mediated hyperplasia and promotes tumor initiation

p16(INK4a) (CDKN2A) is a central tumor suppressor, which induces cell-cycle arrest and senescence. Cells expressing p16(INK4a) accumulate in aging tissues and appear in premalignant lesions, yet their physiologic effects are poorly understood. We found that prolonged expression of transgenic p16(INK...

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Detalles Bibliográficos
Autores principales: Azazmeh, Narmen, Assouline, Benjamin, Winter, Eitan, Ruppo, Shmuel, Nevo, Yuval, Maly, Alexander, Meir, Karen, Witkiewicz, Agnieszka K., Cohen, Jonathan, Rizou, Sophia V., Pikarsky, Eli, Luxenburg, Chen, Gorgoulis, Vassilis G., Ben-Porath, Ittai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264228/
https://www.ncbi.nlm.nih.gov/pubmed/32483135
http://dx.doi.org/10.1038/s41467-020-16475-3

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