Cargando…

Designing antifilarial drug trials using clinical trial simulators

Lymphatic filariasis and onchocerciasis are neglected tropical diseases (NTDs) targeted for elimination by mass (antifilarial) drug administration. These drugs are predominantly active against the microfilarial progeny of adult worms. New drugs or combinations are needed to improve patient therapy a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Walker, Martin, Hamley, Jonathan I. D., Milton, Philip, Monnot, Frédéric, Pedrique, Belén, Basáñez, Maria-Gloria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264235/ https://www.ncbi.nlm.nih.gov/pubmed/32483209 http://dx.doi.org/10.1038/s41467-020-16442-y

Ejemplares similares

Supporting Drug Development for Neglected Tropical Diseases Using Mathematical Modeling
por: Walker, Martin, et al.
Publicado: (2021)

Modelling exposure heterogeneity and density dependence in onchocerciasis using a novel individual-based transmission model, EPIONCHO-IBM: Implications for elimination and data needs
por: Hamley, Jonathan I. D., et al.
Publicado: (2019)

Antifilarial activity of diterpenoids from Taxodium distichum
por: Kushwaha, Vikas, et al.
Publicado: (2016)

Structural Uncertainty in Onchocerciasis Transmission Models Influences the Estimation of Elimination Thresholds and Selection of Age Groups for Seromonitoring
por: Hamley, Jonathan I D, et al.
Publicado: (2020)

Demographic patterns of human antibody levels to Simulium damnosum s.l. saliva in onchocerciasis-endemic areas: An indicator of exposure to vector bites
por: Willen, Laura, et al.
Publicado: (2022)

Antifilarial Lead Molecules Isolated from Trachyspermum ammi
por: Mathew, Nisha, et al.
Publicado: (2008)

Erratum to: Antifilarial activity of diterpenoids from Taxodium distichum
por: Kushwaha, Vikas, et al.
Publicado: (2017)

Current Evidence on the Use of Antifilarial Agents in the Management of Bancroftian Filariasis
por: Fernando, Sumadhya Deepika, et al.
Publicado: (2011)

Antifilarial and Antibiotic Activities of Methanolic Extracts of Melaleuca cajuputi Flowers
por: Al-Abd, Nazeh M., et al.
Publicado: (2016)

Programmed cell death pathways as targets for developing antifilarial drugs: Lessons from the recent findings
por: Das, Nabarun Chandra, et al.
Publicado: (2023)

Predicted binding of certain antifilarial compounds with glutathione-S-transferase of human Filariids
por: Saeed, Mohd, et al.
Publicado: (2013)

Quinolone-fused cyclic sulfonamide as a novel benign antifilarial agent
por: Mukherjee, Suprabhat, et al.
Publicado: (2018)

What does the COVID-19 pandemic mean for the next decade of onchocerciasis control and elimination?
por: Hamley, Jonathan I D, et al.
Publicado: (2021)

Impact of Basic Lymphedema Management and Antifilarial Treatment on Acute Dermatolymphangioadenitis Episodes and Filarial Antigenaemia
por: El-Nahas, HA, et al.
Publicado: (2011)

Antifilarial Activity of the Methanolic Extract of Indigofera tinctoria (Fabaceae) on Bovine Parasites (Onchocerca ochengi)
por: Rakwa, Enock Enock, et al.
Publicado: (2022)

Targeting the Wolbachia Cell Division Protein FtsZ as a New Approach for Antifilarial Therapy
por: Li, Zhiru, et al.
Publicado: (2011)

Scaling-Down Mass Ivermectin Treatment for Onchocerciasis Elimination: Modeling the Impact of the Geographical Unit for Decision Making
por: Stolk, Wilma A, et al.
Publicado: (2021)

Modelling for policy: The five principles of the Neglected Tropical Diseases Modelling Consortium
por: Behrend, Matthew R., et al.
Publicado: (2020)

The Annotated Genome of Wolbachia from the Filarial Nematode Brugia malayi: What It Means for Progress in Antifilarial Medicine
por: Pfarr, Kenneth, et al.
Publicado: (2005)

Longitudinal Monitoring of the Development of Antifilarial Antibodies and Acquisition of Wuchereria bancrofti in a Highly Endemic Area of Haiti
por: Hamlin, Katy L., et al.
Publicado: (2012)

Attenuation of Toll-Like Receptor Expression and Function in Latent Tuberculosis by Coexistent Filarial Infection with Restoration Following Antifilarial Chemotherapy
por: Babu, Subash, et al.
Publicado: (2009)

Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: a randomized placebo-controlled study
por: Hoerauf, Achim, et al.
Publicado: (2007)

Applicability of the Filter Paper Technique for Detection of Antifilarial IgG(4) Antibodies Using the Bm14 Filariasis CELISA
por: Joseph, Hayley M., et al.
Publicado: (2010)

Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: a randomized placebo-controlled study
por: Hoerauf, Achim, et al.
Publicado: (2008)

The potential impact of moxidectin on onchocerciasis elimination in Africa: an economic evaluation based on the Phase II clinical trial data
por: Turner, Hugo C, et al.
Publicado: (2015)

Can mass drug administration of moxidectin accelerate onchocerciasis elimination in Africa?
por: Kura, Klodeta, et al.
Publicado: (2023)

Application of the Filariasis CELISA Antifilarial IgG(4) Antibody Assay in Surveillance in Lymphatic Filariasis Elimination Programmes in the South Pacific
por: Joseph, Hayley, et al.
Publicado: (2011)

Modulation of phosphofructokinase (PFK) from Setaria cervi, a bovine filarial parasite, by different effectors and its interaction with some antifilarials
por: Sharma, Bechan
Publicado: (2011)

Safety, tolerability and pharmacokinetics of emodepside, a potential novel treatment for onchocerciasis (river blindness), in healthy male subjects
por: Gillon, Jean‐Yves, et al.
Publicado: (2021)

Cellular Quantitative Structure–Activity Relationship (Cell-QSAR): Conceptual Dissection of Receptor Binding and Intracellular Disposition in Antifilarial Activities of Selwood Antimycins
por: Natesan, Senthil, et al.
Publicado: (2012)

Innovative highlights of clinical drug trial design
por: Chen, Daohong, et al.
Publicado: (2020)

An R Package for Simulation Experiments Evaluating Clinical Trial Designs
por: Wang, Yuanyuan, et al.
Publicado: (2010)

Elimination of lymphatic filariasis in South East Asia
por: Specht, Sabine, et al.
Publicado: (2019)

Polyphenol enriched ethanolic extract of Cajanus scarabaeoides (L.) Thouars exerts potential antifilarial activity by inducing oxidative stress and programmed cell death
por: Ray, Anindya Sundar, et al.
Publicado: (2018)

Using simulation to aid trial design: Ring-vaccination trials
por: Hitchings, Matt David Thomas, et al.
Publicado: (2017)

Combining Model‐Based Clinical Trial Simulation, Pharmacoeconomics, and Value of Information to Optimize Trial Design
por: Hill‐McManus, Daniel, et al.
Publicado: (2020)

Individual Predisposition, Household Clustering and Risk Factors for Human Infection with Ascaris lumbricoides: New Epidemiological Insights
por: Walker, Martin, et al.
Publicado: (2011)

In the future simulations will replace clinical trials
por: Ebert, Martin A., et al.
Publicado: (2021)

Modelling for Taenia solium control strategies beyond 2020
por: Dixon, Matthew A, et al.
Publicado: (2020)

Clinical Trial Simulation To Optimize Trial Design for Fludarabine Dosing Strategies in Allogeneic Hematopoietic Cell Transplantation
por: Langenhorst, Jurgen B., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_nr69sgjjk9ml0f8nre924ifpg4