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Destabilization of light NREM sleep by thalamic PLCβ4 deletion impairs sleep-dependent memory consolidation
Sleep abnormality often accompanies the impairment of cognitive function. Both rapid eye movement (REM) and non-REM (NREM) sleep have associated with improved memory performance. However, the role of composition in NREM sleep, consisting of light and deep NREM, for memory formation is not fully unde...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264240/ https://www.ncbi.nlm.nih.gov/pubmed/32483199 http://dx.doi.org/10.1038/s41598-020-64377-7 |
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author | Hong, Joohyeon Ha, Go Eun Kwak, Hankyul Lee, Yelin Jeong, Hyeonyeong Suh, Pann-Ghill Cheong, Eunji |
author_facet | Hong, Joohyeon Ha, Go Eun Kwak, Hankyul Lee, Yelin Jeong, Hyeonyeong Suh, Pann-Ghill Cheong, Eunji |
author_sort | Hong, Joohyeon |
collection | PubMed |
description | Sleep abnormality often accompanies the impairment of cognitive function. Both rapid eye movement (REM) and non-REM (NREM) sleep have associated with improved memory performance. However, the role of composition in NREM sleep, consisting of light and deep NREM, for memory formation is not fully understood. We investigated how the dynamics of NREM sleep states influence memory consolidation. Thalamocortical (TC) neuron-specific phospholipase C β4 (PLCβ4) knockout (KO) increased the total duration of NREM sleep, consisting of destabilized light NREM and stabilized deep NREM. Surprisingly, the longer NREM sleep did not improve memory consolidation but rather impaired it in TC-specific PLCβ4 KO mice. Memory function was positively correlated with the stability of light NREM and spindle activity occurring in maintained light NREM period. Our study suggests that a single molecule, PLCβ4, in TC neurons is critical for tuning the NREM sleep states and thus affects sleep-dependent memory formation. |
format | Online Article Text |
id | pubmed-7264240 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-72642402020-06-05 Destabilization of light NREM sleep by thalamic PLCβ4 deletion impairs sleep-dependent memory consolidation Hong, Joohyeon Ha, Go Eun Kwak, Hankyul Lee, Yelin Jeong, Hyeonyeong Suh, Pann-Ghill Cheong, Eunji Sci Rep Article Sleep abnormality often accompanies the impairment of cognitive function. Both rapid eye movement (REM) and non-REM (NREM) sleep have associated with improved memory performance. However, the role of composition in NREM sleep, consisting of light and deep NREM, for memory formation is not fully understood. We investigated how the dynamics of NREM sleep states influence memory consolidation. Thalamocortical (TC) neuron-specific phospholipase C β4 (PLCβ4) knockout (KO) increased the total duration of NREM sleep, consisting of destabilized light NREM and stabilized deep NREM. Surprisingly, the longer NREM sleep did not improve memory consolidation but rather impaired it in TC-specific PLCβ4 KO mice. Memory function was positively correlated with the stability of light NREM and spindle activity occurring in maintained light NREM period. Our study suggests that a single molecule, PLCβ4, in TC neurons is critical for tuning the NREM sleep states and thus affects sleep-dependent memory formation. Nature Publishing Group UK 2020-06-01 /pmc/articles/PMC7264240/ /pubmed/32483199 http://dx.doi.org/10.1038/s41598-020-64377-7 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Hong, Joohyeon Ha, Go Eun Kwak, Hankyul Lee, Yelin Jeong, Hyeonyeong Suh, Pann-Ghill Cheong, Eunji Destabilization of light NREM sleep by thalamic PLCβ4 deletion impairs sleep-dependent memory consolidation |
title | Destabilization of light NREM sleep by thalamic PLCβ4 deletion impairs sleep-dependent memory consolidation |
title_full | Destabilization of light NREM sleep by thalamic PLCβ4 deletion impairs sleep-dependent memory consolidation |
title_fullStr | Destabilization of light NREM sleep by thalamic PLCβ4 deletion impairs sleep-dependent memory consolidation |
title_full_unstemmed | Destabilization of light NREM sleep by thalamic PLCβ4 deletion impairs sleep-dependent memory consolidation |
title_short | Destabilization of light NREM sleep by thalamic PLCβ4 deletion impairs sleep-dependent memory consolidation |
title_sort | destabilization of light nrem sleep by thalamic plcβ4 deletion impairs sleep-dependent memory consolidation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264240/ https://www.ncbi.nlm.nih.gov/pubmed/32483199 http://dx.doi.org/10.1038/s41598-020-64377-7 |
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