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Inactivation of Arid1a in the endometrium is associated with endometrioid tumorigenesis through transcriptional reprogramming

Somatic inactivating mutations of ARID1A, a SWI/SNF chromatin remodeling gene, are prevalent in human endometrium-related malignancies. To elucidate the mechanisms underlying how ARID1A deleterious mutation contributes to tumorigenesis, we establish genetically engineered murine models with Arid1a a...

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Detalles Bibliográficos
Autores principales:	Suryo Rahmanto, Yohan, Shen, Wenjing, Shi, Xu, Chen, Xi, Yu, Yu, Yu, Zheng-Cheng, Miyamoto, Tsutomu, Lee, Meng-Horng, Singh, Vivek, Asaka, Ryoichi, Shimberg, Geoffrey, Vitolo, Michele I., Martin, Stuart S., Wirtz, Denis, Drapkin, Ronny, Xuan, Jianhua, Wang, Tian-Li, Shih, Ie-Ming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264300/ https://www.ncbi.nlm.nih.gov/pubmed/32483112 http://dx.doi.org/10.1038/s41467-020-16416-0

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