Improving the safety of human pluripotent stem cell therapies using genome-edited orthogonal safeguards

Despite their rapidly-expanding therapeutic potential, human pluripotent stem cell (hPSC)-derived cell therapies continue to have serious safety risks. Transplantation of hPSC-derived cell populations into preclinical models has generated teratomas (tumors arising from undifferentiated hPSCs), unwan...

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Detalles Bibliográficos
Autores principales: Martin, Renata M., Fowler, Jonas L., Cromer, M. Kyle, Lesch, Benjamin J., Ponce, Ezequiel, Uchida, Nobuko, Nishimura, Toshinobu, Porteus, Matthew H., Loh, Kyle M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264334/
https://www.ncbi.nlm.nih.gov/pubmed/32483127
http://dx.doi.org/10.1038/s41467-020-16455-7

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