Cargando…

AAV-CRISPR Gene Editing Is Negated by Pre-existing Immunity to Cas9

Adeno-associated viral (AAV) vectors are a leading candidate for the delivery of CRISPR-Cas9 for therapeutic genome editing in vivo. However, AAV-based delivery involves persistent expression of the Cas9 nuclease, a bacterial protein. Recent studies indicate a high prevalence of neutralizing antibod...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Ang, Tanner, Mark R., Lee, Ciaran M., Hurley, Ayrea E., De Giorgi, Marco, Jarrett, Kelsey E., Davis, Timothy H., Doerfler, Alexandria M., Bao, Gang, Beeton, Christine, Lagor, William R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2020
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264438/ https://www.ncbi.nlm.nih.gov/pubmed/32348718 http://dx.doi.org/10.1016/j.ymthe.2020.04.017

Ejemplares similares

A Self-Deleting AAV-CRISPR System for In Vivo Genome Editing
por: Li, Ang, et al.
Publicado: (2018)

LPA disruption with AAV-CRISPR potently lowers plasma apo(a) in transgenic mouse model: A proof-of-concept study
por: Doerfler, Alexandria M., et al.
Publicado: (2022)

Adeno-Associated virus 8 delivers an immunomodulatory peptide to mouse liver more efficiently than to rat liver
por: Wang, Yuqing, et al.
Publicado: (2023)

Somatic genome editing with CRISPR/Cas9 generates and corrects a metabolic disease
por: Jarrett, Kelsey E., et al.
Publicado: (2017)

Treating Cardiovascular Disease with Liver Genome Engineering
por: Hurley, Ayrea, et al.
Publicado: (2022)

In vivo genome editing at the albumin locus to treat methylmalonic acidemia
por: Schneller, Jessica L., et al.
Publicado: (2021)

AAV-Mediated CRISPR/Cas9 Gene Editing in Murine Phenylketonuria
por: Richards, Daelyn Y., et al.
Publicado: (2019)

Targeting the Apoa1 locus for liver-directed gene therapy
por: De Giorgi, Marco, et al.
Publicado: (2021)

Chromothripsis as an on-target consequence of CRISPR-Cas9 genome editing
por: Leibowitz, Mitchell L., et al.
Publicado: (2021)

Genome Editing With TALEN, CRISPR-Cas9 and CRISPR-Cas12a in Combination With AAV6 Homology Donor Restores T Cell Function for XLP
por: Houghton, Benjamin C., et al.
Publicado: (2022)

Dynamics and competition of CRISPR–Cas9 ribonucleoproteins and AAV donor-mediated NHEJ, MMEJ and HDR editing
por: Fu, Ya-Wen, et al.
Publicado: (2021)

CRISPR-Cas9 DNA Base-Editing and Prime-Editing
por: Kantor, Ariel, et al.
Publicado: (2020)

CRISPR/Cas9-mediated genome editing via postnatal administration of AAV vector cures haemophilia B mice
por: Ohmori, Tsukasa, et al.
Publicado: (2017)

Spatial control of in vivo CRISPR–Cas9 genome editing via nanomagnets
por: Zhu, Haibao, et al.
Publicado: (2018)

An AAV-CRISPR/Cas9 strategy for gene editing across divergent rodent species: Targeting neural oxytocin receptors as a proof of concept
por: Boender, Arjen J., et al.
Publicado: (2023)

Inducible in vivo genome editing with CRISPR/Cas9
por: Dow, Lukas E, et al.
Publicado: (2015)

The Neisseria meningitidis CRISPR-Cas9 System Enables Specific Genome Editing in Mammalian Cells
por: Lee, Ciaran M, et al.
Publicado: (2016)

Long-term Evaluation of AAV-CRISPR Genome Editing for Duchenne Muscular Dystrophy
por: Nelson, Christopher E., et al.
Publicado: (2019)

CRISPR/Cas9 as an antiviral against Orthopoxviruses using an AAV vector
por: Siegrist, Cathryn M., et al.
Publicado: (2020)

Self-delivering CRISPR RNAs for AAV Co-delivery and Genome Editing in vivo
por: Zhang, Han, et al.
Publicado: (2023)

Single AAV-Mediated CRISPR-SaCas9 Inhibits HSV-1 Replication by Editing ICP4 in Trigeminal Ganglion Neurons
por: Chen, Yuxi, et al.
Publicado: (2020)

Molecular dynamics of genome editing with CRISPR-Cas9 and rAAV6 virus in human HSPCs to treat sickle cell disease
por: Xu, Liwen, et al.
Publicado: (2023)

Genome Editing in Cotton with the CRISPR/Cas9 System
por: Gao, Wei, et al.
Publicado: (2017)

Commentary: RNA editing with CRISPR-Cas13
por: Matsoukas, Ianis G.
Publicado: (2018)

Genome Editing in Bacteria: CRISPR-Cas and Beyond
por: Arroyo-Olarte, Ruben D., et al.
Publicado: (2021)

CRISPR/Cas9 or prime editing? – It depends on…
por: Schenke, Dirk
Publicado: (2020)

Development of an AAV-CRISPR-Cas9-based treatment for dominant cone-rod dystrophy 6
por: Mellen, Russell W., et al.
Publicado: (2023)

Pre-existing immunity does not impair the engraftment of CRISPR-Cas9-edited cells in rhesus macaques conditioned with busulfan or radiation
por: Essawi, Khaled, et al.
Publicado: (2023)

The Development of an AAV-Based CRISPR SaCas9 Genome Editing System That Can Be Delivered to Neurons in vivo and Regulated via Doxycycline and Cre-Recombinase
por: Kumar, Namrata, et al.
Publicado: (2018)

A Guild of 45 CRISPR-Associated (Cas) Protein Families and Multiple CRISPR/Cas Subtypes Exist in Prokaryotic Genomes
por: Haft, Daniel H, et al.
Publicado: (2005)

CRISPR/Cas9/AAV9-mediated in vivo editing identifies MYC regulation of 3D genome in skeletal muscle stem cell
por: He, Liangqiang, et al.
Publicado: (2021)

TALEN and CRISPR/Cas Genome Editing Systems: Tools of Discovery
por: Nemudryi, A. A., et al.
Publicado: (2014)

Targeted activation of diverse CRISPR-Cas systems for mammalian genome editing via proximal CRISPR targeting
por: Chen, Fuqiang, et al.
Publicado: (2017)

Genome Editing with AAV-BR1-CRISPR in Postnatal Mouse Brain Endothelial Cells
por: Song, Xiaopeng, et al.
Publicado: (2022)

Epigenetic Footprints of CRISPR/Cas9-Mediated Genome Editing in Plants
por: Lee, Jun Hyung, et al.
Publicado: (2020)

The Rise of CRISPR/Cas for Genome Editing in Stem Cells
por: Shui, Bing, et al.
Publicado: (2016)

Efficient Mitochondrial Genome Editing by CRISPR/Cas9
por: Jo, Areum, et al.
Publicado: (2015)

Multiplex genome editing of microorganisms using CRISPR-Cas
por: Adiego-Pérez, Belén, et al.
Publicado: (2019)

CRISPR/Cas9: Transcending the Reality of Genome Editing
por: Chira, Sergiu, et al.
Publicado: (2017)

Delivery Aspects of CRISPR/Cas for in Vivo Genome Editing
por: Wilbie, Danny, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_cj613snvthqe05bjao3repjnnb