Cargando…

Crystal structure of Nsp15 endoribonuclease NendoU from SARS‐CoV‐2

Severe Acute Respiratory Syndrome coronavirus 2 (SARS‐CoV‐2) is rapidly spreading around the world. There is no existing vaccine or proven drug to prevent infections and stop virus proliferation. Although this virus is similar to human and animal SARS‐CoVs and Middle East Respiratory Syndrome corona...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Youngchang, Jedrzejczak, Robert, Maltseva, Natalia I., Wilamowski, Mateusz, Endres, Michael, Godzik, Adam, Michalska, Karolina, Joachimiak, Andrzej
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2020
Materias:	Full‐length Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264519/ https://www.ncbi.nlm.nih.gov/pubmed/32304108 http://dx.doi.org/10.1002/pro.3873

Ejemplares similares

Tipiracil binds to uridine site and inhibits Nsp15 endoribonuclease NendoU from SARS-CoV-2
por: Kim, Youngchang, et al.
Publicado: (2021)

Overcoming nonstructural protein 15-nidoviral uridylate-specific endoribonuclease (nsp15/NendoU) activity of SARS-CoV-2
por: Senanayake, Suranga L
Publicado: (2020)

Structural and biochemical analysis of the metallo‐β‐lactamase L1 from emerging pathogen Stenotrophomonas maltophilia revealed the subtle but distinct di‐metal scaffold for catalytic activity
por: Kim, Youngchang, et al.
Publicado: (2019)

Room-temperature structural studies of SARS-CoV-2 protein NendoU with an X-ray free-electron laser
por: Jernigan, Rebecca J., et al.
Publicado: (2023)

Crystal structures of SARS-CoV-2 ADP-ribose phosphatase: from the apo form to ligand complexes
por: Michalska, Karolina, et al.
Publicado: (2020)

The crystal structure of nsp10-nsp16 heterodimer from SARS-CoV-2 in complex with S-adenosylmethionine
por: Rosas-Lemus, Monica, et al.
Publicado: (2020)

Transient and stabilized complexes of Nsp7, Nsp8, and Nsp12 in SARS-CoV-2 replication
por: Wilamowski, Mateusz, et al.
Publicado: (2021)

Reversible and irreversible inhibitors of coronavirus Nsp15 endoribonuclease
por: Chen, Jerry, et al.
Publicado: (2023)

Catalytically impaired TrpA subunit of tryptophan synthase from Chlamydia trachomatis is an allosteric regulator of TrpB
por: Michalska, Karolina, et al.
Publicado: (2021)

Substrate specificity of human MCPIP1 endoribonuclease
por: Wilamowski, Mateusz, et al.
Publicado: (2018)

2′-O methylation of RNA cap in SARS-CoV-2 captured by serial crystallography
por: Wilamowski, Mateusz, et al.
Publicado: (2021)

Cryo-EM Structures of the SARS-CoV-2 Endoribonuclease Nsp15
por: Pillon, Monica C., et al.
Publicado: (2020)

Structural and Functional Analyses of the Severe Acute Respiratory Syndrome Coronavirus Endoribonuclease Nsp15
por: Bhardwaj, Kanchan, et al.
Publicado: (2008)

Biochemical Characterization of Emerging SARS-CoV-2 Nsp15 Endoribonuclease Variants
por: Wilson, Isha M., et al.
Publicado: (2022)

Biochemical Characterization of Emerging SARS-CoV-2 Nsp15 Endoribonuclease Variants
por: Wilson, Isha M., et al.
Publicado: (2022)

Porcine deltacoronavirus nsp15 antagonizes interferon-β production independently of its endoribonuclease activity
por: Liu, Xiaorong, et al.
Publicado: (2019)

Mutational Analysis of the SARS Virus Nsp15 Endoribonuclease: Identification of Residues Affecting Hexamer Formation
por: Guarino, Linda A., et al.
Publicado: (2005)

Evaluation of action of steroid molecules on SARS-CoV-2 by inhibiting NSP-15, an endoribonuclease
por: Dhanabalan, Anantha Krishnan, et al.
Publicado: (2022)

Allosteric regulation and crystallographic fragment screening of SARS-CoV-2 NSP15 endoribonuclease
por: Godoy, Andre Schutzer, et al.
Publicado: (2023)

Functional and Structural Characterization of Diverse NfsB Chloramphenicol Reductase Enzymes from Human Pathogens
por: Mullowney, Michael W., et al.
Publicado: (2022)

Structure and enzymatic characterization of CelD endoglucanase from the anaerobic fungus Piromyces finnis
por: Dementiev, Alexey, et al.
Publicado: (2023)

Comparative in vivo analysis of the nsp15 endoribonuclease of murine, porcine and severe acute respiratory syndrome coronaviruses
por: Cao, Jianzhong, et al.
Publicado: (2012)

Molecular Docking of Cyanine and Squarylium Dyes with NSP15 Endoribonuclease of the SARS-CoV-2 Coronavirus
por: Pronkin, P. G., et al.
Publicado: (2022)

Insight into the evolution of nidovirus endoribonuclease based on the finding that nsp15 from porcine Deltacoronavirus functions as a dimer
por: Zheng, Anjun, et al.
Publicado: (2018)

Pharmacoinformatics approach based identification of potential Nsp15 endoribonuclease modulators for SARS-CoV-2 inhibition
por: Savale, Rutuja Umesh, et al.
Publicado: (2021)

Inhibition of anti-viral stress granule formation by coronavirus endoribonuclease nsp15 ensures efficient virus replication
por: Gao, Bo, et al.
Publicado: (2021)

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp15 endoribonuclease
por: Canal, Berta, et al.
Publicado: (2021)

Dual domain recognition determines SARS-CoV-2 PLpro selectivity for human ISG15 and K48-linked di-ubiquitin
por: Wydorski, Pawel M., et al.
Publicado: (2023)

Dual domain recognition determines SARS-CoV-2 PLpro selectivity for human ISG15 and K48-linked di-ubiquitin
por: Wydorski, Pawel M., et al.
Publicado: (2023)

Structure-based drug designing towards the identification of potential anti-viral for COVID-19 by targeting endoribonuclease NSP15
por: Krishnan, D. Anantha, et al.
Publicado: (2020)

Identification of Persuasive Antiviral Natural Compounds for COVID-19 by Targeting Endoribonuclease NSP15: A Structural-Bioinformatics Approach
por: Saeed, Mohd, et al.
Publicado: (2020)

Cryo-EM structures of the SARS-CoV-2 endoribonuclease Nsp15 reveal insight into nuclease specificity and dynamics
por: Pillon, Monica C., et al.
Publicado: (2021)

Antibiotic-Induced Primary Biles Inhibit SARS-CoV-2 Endoribonuclease Nsp15 Activity in Mouse Gut
por: Ma, Yao, et al.
Publicado: (2022)

Identification and characterization of E266Q mutation in Nsp15 endoribonuclease from SARS-CoV-2 Epsilon variant
por: Sonowal, Manashi, et al.
Publicado: (2023)

Endoribonuclease activities of porcine reproductive and respiratory syndrome virus nsp11 was essential for nsp11 to inhibit IFN-β induction
por: Shi, Xibao, et al.
Publicado: (2011)

Fixed-target serial crystallography at the Structural Biology Center
por: Sherrell, Darren A., et al.
Publicado: (2022)

Crystal structure of SARS‐CoV‐2 nsp10–nsp16 in complex with small molecule inhibitors, SS148 and WZ16
por: Klima, Martin, et al.
Publicado: (2022)

Structural genomics and the Protein Data Bank
por: Michalska, Karolina, et al.
Publicado: (2021)

A Dimerization-Dependent Mechanism Drives the Endoribonuclease Function of Porcine Reproductive and Respiratory Syndrome Virus nsp11
por: Shi, Yuejun, et al.
Publicado: (2016)

Large-scale purification and crystallization of the endoribonuclease XendoU: troubleshooting with His-tagged proteins
por: Renzi, Fabiana, et al.
Publicado: (2006)

Cannot write session to /tmp/vufind_sessions/sess_oj70mvjf5olgp0vog6img1h6d8