Blood clots and TAM receptor signalling in COVID-19 pathogenesis

We suggest that the exuberant blood clotting and immune hyper-reaction seen in patients with COVID-19 may be exacerbated by depletion of the same regulator. This agent is protein S, which is both an anticoagulant in the blood coagulation cascade and an activating ligand for the immunosuppressive TAM...

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Detalles Bibliográficos
Autores principales: Lemke, Greg, Silverman, Gregg J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264968/
https://www.ncbi.nlm.nih.gov/pubmed/32488201
http://dx.doi.org/10.1038/s41577-020-0354-x
Descripción
Sumario:We suggest that the exuberant blood clotting and immune hyper-reaction seen in patients with COVID-19 may be exacerbated by depletion of the same regulator. This agent is protein S, which is both an anticoagulant in the blood coagulation cascade and an activating ligand for the immunosuppressive TAM family of receptor tyrosine kinases.

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