Blood clots and TAM receptor signalling in COVID-19 pathogenesis

We suggest that the exuberant blood clotting and immune hyper-reaction seen in patients with COVID-19 may be exacerbated by depletion of the same regulator. This agent is protein S, which is both an anticoagulant in the blood coagulation cascade and an activating ligand for the immunosuppressive TAM...

Descripción completa

Detalles Bibliográficos
Autores principales: Lemke, Greg, Silverman, Gregg J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264968/
https://www.ncbi.nlm.nih.gov/pubmed/32488201
http://dx.doi.org/10.1038/s41577-020-0354-x
_version_ 1783541041159208960
author Lemke, Greg
Silverman, Gregg J.
author_facet Lemke, Greg
Silverman, Gregg J.
author_sort Lemke, Greg
collection PubMed
description We suggest that the exuberant blood clotting and immune hyper-reaction seen in patients with COVID-19 may be exacerbated by depletion of the same regulator. This agent is protein S, which is both an anticoagulant in the blood coagulation cascade and an activating ligand for the immunosuppressive TAM family of receptor tyrosine kinases.
format Online
Article
Text
id pubmed-7264968
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-72649682020-06-02 Blood clots and TAM receptor signalling in COVID-19 pathogenesis Lemke, Greg Silverman, Gregg J. Nat Rev Immunol Comment We suggest that the exuberant blood clotting and immune hyper-reaction seen in patients with COVID-19 may be exacerbated by depletion of the same regulator. This agent is protein S, which is both an anticoagulant in the blood coagulation cascade and an activating ligand for the immunosuppressive TAM family of receptor tyrosine kinases. Nature Publishing Group UK 2020-06-02 2020 /pmc/articles/PMC7264968/ /pubmed/32488201 http://dx.doi.org/10.1038/s41577-020-0354-x Text en © Springer Nature Limited 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Comment
Lemke, Greg
Silverman, Gregg J.
Blood clots and TAM receptor signalling in COVID-19 pathogenesis
title Blood clots and TAM receptor signalling in COVID-19 pathogenesis
title_full Blood clots and TAM receptor signalling in COVID-19 pathogenesis
title_fullStr Blood clots and TAM receptor signalling in COVID-19 pathogenesis
title_full_unstemmed Blood clots and TAM receptor signalling in COVID-19 pathogenesis
title_short Blood clots and TAM receptor signalling in COVID-19 pathogenesis
title_sort blood clots and tam receptor signalling in covid-19 pathogenesis
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264968/
https://www.ncbi.nlm.nih.gov/pubmed/32488201
http://dx.doi.org/10.1038/s41577-020-0354-x
work_keys_str_mv AT lemkegreg bloodclotsandtamreceptorsignallingincovid19pathogenesis
AT silvermangreggj bloodclotsandtamreceptorsignallingincovid19pathogenesis

Ejemplares similares