Cargando…

Neuropathic Pain Component Insights in Patients with Knee Osteoarthritis: An Observational Study

Osteoarthritis (OA) is one of the most leading cause of chronic disability in musculoskeletal area with pain as the main manifestation. Chronic pain often leads to an abnormal excitability in pain pathway, resulting a central sensitization which corresponding to neuropathic pain (NP). To date, the e...

Descripción completa

Detalles Bibliográficos
Autores principales: Prapto, Devindra, Tertia, Clarissa, Purvance, Ivander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265210/
http://dx.doi.org/10.1177/2325967120S00057
_version_ 1783541085493002240
author Prapto, Devindra
Tertia, Clarissa
Purvance, Ivander
author_facet Prapto, Devindra
Tertia, Clarissa
Purvance, Ivander
author_sort Prapto, Devindra
collection PubMed
description Osteoarthritis (OA) is one of the most leading cause of chronic disability in musculoskeletal area with pain as the main manifestation. Chronic pain often leads to an abnormal excitability in pain pathway, resulting a central sensitization which corresponding to neuropathic pain (NP). To date, the existence of neuropathic component in osteoarthritis of the knee remains controversial. METHODS: The cross-sectional study involved 74 patients of knee osteoarthritis who were diagnosed by using ACR classification criteria for osteoarthritis of the knee. The presence of NP component was assessed by DN4 and painDETECT questionnaire. All participant also completed the WOMAC score to evaluate their status of knee OA, and was divided into two groups, which were mild and severe OA. The prevalence of NP component within knee OA patients was evaluated and then compared between the mild and severe groups. RESULTS: 45,9% of the participants examined with DN4 score were likely to have the NP component, while the others were doubtful. On the other hand, painDETECT score revealed that 36,5% of the patients were likely to have NP component, 21,6% unclear, and 41,9% unlikely. Comparison between WOMAC score and DN4 showed that 67,6% of the severe population had NP component, significantly higher than the mild population, 24,3% (p<0,05). Alternatively, painDETECT score showed 13,5% likely to have NP component, 24,3% unclear, 62,2% doubtful in the mild population, while in the severe group 59,5% likely, 18,9% unclear, 21,6% unlikely (p<0,05). CONCLUSION: Knee osteoarthritis has a significantly high prevalence of neuropathic pain component. NP component prevalence appears higher in the severe OA population, whether it assessed by DN4 or painDETECT scoring.
format Online
Article
Text
id pubmed-7265210
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher SAGE Publications
record_format MEDLINE/PubMed
spelling pubmed-72652102020-06-10 Neuropathic Pain Component Insights in Patients with Knee Osteoarthritis: An Observational Study Prapto, Devindra Tertia, Clarissa Purvance, Ivander Orthop J Sports Med Article Osteoarthritis (OA) is one of the most leading cause of chronic disability in musculoskeletal area with pain as the main manifestation. Chronic pain often leads to an abnormal excitability in pain pathway, resulting a central sensitization which corresponding to neuropathic pain (NP). To date, the existence of neuropathic component in osteoarthritis of the knee remains controversial. METHODS: The cross-sectional study involved 74 patients of knee osteoarthritis who were diagnosed by using ACR classification criteria for osteoarthritis of the knee. The presence of NP component was assessed by DN4 and painDETECT questionnaire. All participant also completed the WOMAC score to evaluate their status of knee OA, and was divided into two groups, which were mild and severe OA. The prevalence of NP component within knee OA patients was evaluated and then compared between the mild and severe groups. RESULTS: 45,9% of the participants examined with DN4 score were likely to have the NP component, while the others were doubtful. On the other hand, painDETECT score revealed that 36,5% of the patients were likely to have NP component, 21,6% unclear, and 41,9% unlikely. Comparison between WOMAC score and DN4 showed that 67,6% of the severe population had NP component, significantly higher than the mild population, 24,3% (p<0,05). Alternatively, painDETECT score showed 13,5% likely to have NP component, 24,3% unclear, 62,2% doubtful in the mild population, while in the severe group 59,5% likely, 18,9% unclear, 21,6% unlikely (p<0,05). CONCLUSION: Knee osteoarthritis has a significantly high prevalence of neuropathic pain component. NP component prevalence appears higher in the severe OA population, whether it assessed by DN4 or painDETECT scoring. SAGE Publications 2020-05-29 /pmc/articles/PMC7265210/ http://dx.doi.org/10.1177/2325967120S00057 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc-nd/4.0/ This open-access article is published and distributed under the Creative Commons Attribution - NonCommercial - No Derivatives License (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits the noncommercial use, distribution, and reproduction of the article in any medium, provided the original author and source are credited. You may not alter, transform, or build upon this article without the permission of the Author(s). For article reuse guidelines, please visit SAGE’s website at http://www.sagepub.com/journals-permissions.
spellingShingle Article
Prapto, Devindra
Tertia, Clarissa
Purvance, Ivander
Neuropathic Pain Component Insights in Patients with Knee Osteoarthritis: An Observational Study
title Neuropathic Pain Component Insights in Patients with Knee Osteoarthritis: An Observational Study
title_full Neuropathic Pain Component Insights in Patients with Knee Osteoarthritis: An Observational Study
title_fullStr Neuropathic Pain Component Insights in Patients with Knee Osteoarthritis: An Observational Study
title_full_unstemmed Neuropathic Pain Component Insights in Patients with Knee Osteoarthritis: An Observational Study
title_short Neuropathic Pain Component Insights in Patients with Knee Osteoarthritis: An Observational Study
title_sort neuropathic pain component insights in patients with knee osteoarthritis: an observational study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265210/
http://dx.doi.org/10.1177/2325967120S00057
work_keys_str_mv AT praptodevindra neuropathicpaincomponentinsightsinpatientswithkneeosteoarthritisanobservationalstudy
AT tertiaclarissa neuropathicpaincomponentinsightsinpatientswithkneeosteoarthritisanobservationalstudy
AT purvanceivander neuropathicpaincomponentinsightsinpatientswithkneeosteoarthritisanobservationalstudy