Cargando…
Topographic distinction in long-term value signals between presumed dopamine neurons and presumed striatal projection neurons in behaving monkeys
Nigrostriatal dopamine (DA) projections are anatomically organized along the dorsolateral-ventromedial axis, conveying long-term value signals to the striatum for shaping actions toward multiple future rewards. The present study examines whether the topographic organization of long-term value signal...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265398/ https://www.ncbi.nlm.nih.gov/pubmed/32488042 http://dx.doi.org/10.1038/s41598-020-65914-0 |
_version_ | 1783541124645781504 |
---|---|
author | Enomoto, Kazuki Matsumoto, Naoyuki Inokawa, Hitoshi Kimura, Minoru Yamada, Hiroshi |
author_facet | Enomoto, Kazuki Matsumoto, Naoyuki Inokawa, Hitoshi Kimura, Minoru Yamada, Hiroshi |
author_sort | Enomoto, Kazuki |
collection | PubMed |
description | Nigrostriatal dopamine (DA) projections are anatomically organized along the dorsolateral-ventromedial axis, conveying long-term value signals to the striatum for shaping actions toward multiple future rewards. The present study examines whether the topographic organization of long-term value signals are observed upon activity of presumed DA neurons and presumed striatal projection neurons (phasically active neurons, PANs), as predicted based on anatomical literature. Our results indicate that DA neurons in the dorsolateral midbrain encode long-term value signals on a short timescale, while ventromedial midbrain DA neurons encode such signals on a relatively longer timescale. Activity of the PANs in the dorsal striatum is more heterogeneous for encoding long-term values, although significant differences in long-term value signals were observed between the caudate nucleus and putamen. These findings suggest that topographic DA signals for long-term values are not simply transferred to striatal neurons, possibly due to the contribution of other projections to the striatum. |
format | Online Article Text |
id | pubmed-7265398 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-72653982020-06-05 Topographic distinction in long-term value signals between presumed dopamine neurons and presumed striatal projection neurons in behaving monkeys Enomoto, Kazuki Matsumoto, Naoyuki Inokawa, Hitoshi Kimura, Minoru Yamada, Hiroshi Sci Rep Article Nigrostriatal dopamine (DA) projections are anatomically organized along the dorsolateral-ventromedial axis, conveying long-term value signals to the striatum for shaping actions toward multiple future rewards. The present study examines whether the topographic organization of long-term value signals are observed upon activity of presumed DA neurons and presumed striatal projection neurons (phasically active neurons, PANs), as predicted based on anatomical literature. Our results indicate that DA neurons in the dorsolateral midbrain encode long-term value signals on a short timescale, while ventromedial midbrain DA neurons encode such signals on a relatively longer timescale. Activity of the PANs in the dorsal striatum is more heterogeneous for encoding long-term values, although significant differences in long-term value signals were observed between the caudate nucleus and putamen. These findings suggest that topographic DA signals for long-term values are not simply transferred to striatal neurons, possibly due to the contribution of other projections to the striatum. Nature Publishing Group UK 2020-06-02 /pmc/articles/PMC7265398/ /pubmed/32488042 http://dx.doi.org/10.1038/s41598-020-65914-0 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Enomoto, Kazuki Matsumoto, Naoyuki Inokawa, Hitoshi Kimura, Minoru Yamada, Hiroshi Topographic distinction in long-term value signals between presumed dopamine neurons and presumed striatal projection neurons in behaving monkeys |
title | Topographic distinction in long-term value signals between presumed dopamine neurons and presumed striatal projection neurons in behaving monkeys |
title_full | Topographic distinction in long-term value signals between presumed dopamine neurons and presumed striatal projection neurons in behaving monkeys |
title_fullStr | Topographic distinction in long-term value signals between presumed dopamine neurons and presumed striatal projection neurons in behaving monkeys |
title_full_unstemmed | Topographic distinction in long-term value signals between presumed dopamine neurons and presumed striatal projection neurons in behaving monkeys |
title_short | Topographic distinction in long-term value signals between presumed dopamine neurons and presumed striatal projection neurons in behaving monkeys |
title_sort | topographic distinction in long-term value signals between presumed dopamine neurons and presumed striatal projection neurons in behaving monkeys |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265398/ https://www.ncbi.nlm.nih.gov/pubmed/32488042 http://dx.doi.org/10.1038/s41598-020-65914-0 |
work_keys_str_mv | AT enomotokazuki topographicdistinctioninlongtermvaluesignalsbetweenpresumeddopamineneuronsandpresumedstriatalprojectionneuronsinbehavingmonkeys AT matsumotonaoyuki topographicdistinctioninlongtermvaluesignalsbetweenpresumeddopamineneuronsandpresumedstriatalprojectionneuronsinbehavingmonkeys AT inokawahitoshi topographicdistinctioninlongtermvaluesignalsbetweenpresumeddopamineneuronsandpresumedstriatalprojectionneuronsinbehavingmonkeys AT kimuraminoru topographicdistinctioninlongtermvaluesignalsbetweenpresumeddopamineneuronsandpresumedstriatalprojectionneuronsinbehavingmonkeys AT yamadahiroshi topographicdistinctioninlongtermvaluesignalsbetweenpresumeddopamineneuronsandpresumedstriatalprojectionneuronsinbehavingmonkeys |