IRAP-dependent endosomal T cell receptor signalling is essential for T cell responses

T cell receptor (TCR) activation is modulated by mechanisms such as TCR endocytosis, which is thought to terminate TCR signalling. Here we show that, upon internalization, TCR continues to signal from a set of specialized endosomes that are crucial for T cell functions. Mechanistically, TCR ligation...

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Detalles Bibliográficos
Autores principales: Evnouchidou, Irini, Chappert, Pascal, Benadda, Samira, Zucchetti, Andres, Weimershaus, Mirjana, Bens, Marcelle, Caillens, Vivien, Koumantou, Despoina, Lotersztajn, Sophie, van Endert, Peter, Davoust, Jean, Guermonprez, Pierre, Hivroz, Claire, Gross, David A., Saveanu, Loredana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265453/
https://www.ncbi.nlm.nih.gov/pubmed/32487999
http://dx.doi.org/10.1038/s41467-020-16471-7

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