The vaccinia virus based Sementis Copenhagen Vector vaccine against Zika and chikungunya is immunogenic in non-human primates

The Sementis Copenhagen Vector (SCV) is a new vaccinia virus-derived, multiplication-defective, vaccine technology assessed herein in non-human primates. Indian rhesus macaques (Macaca mulatta) were vaccinated with a multi-pathogen recombinant SCV vaccine encoding the structural polyproteins of both...

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Autores principales: Prow, Natalie A., Liu, Liang, McCarthy, Mary K., Walters, Kevin, Kalkeri, Raj, Geiger, Jillian, Koide, Fusataka, Cooper, Tamara H., Eldi, Preethi, Nakayama, Eri, Diener, Kerrilyn R., Howley, Paul M., Hayball, John D., Morrison, Thomas E., Suhrbier, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265471/
https://www.ncbi.nlm.nih.gov/pubmed/32550013
http://dx.doi.org/10.1038/s41541-020-0191-8
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author Prow, Natalie A.
Liu, Liang
McCarthy, Mary K.
Walters, Kevin
Kalkeri, Raj
Geiger, Jillian
Koide, Fusataka
Cooper, Tamara H.
Eldi, Preethi
Nakayama, Eri
Diener, Kerrilyn R.
Howley, Paul M.
Hayball, John D.
Morrison, Thomas E.
Suhrbier, Andreas
author_facet Prow, Natalie A.
Liu, Liang
McCarthy, Mary K.
Walters, Kevin
Kalkeri, Raj
Geiger, Jillian
Koide, Fusataka
Cooper, Tamara H.
Eldi, Preethi
Nakayama, Eri
Diener, Kerrilyn R.
Howley, Paul M.
Hayball, John D.
Morrison, Thomas E.
Suhrbier, Andreas
author_sort Prow, Natalie A.
collection PubMed
description The Sementis Copenhagen Vector (SCV) is a new vaccinia virus-derived, multiplication-defective, vaccine technology assessed herein in non-human primates. Indian rhesus macaques (Macaca mulatta) were vaccinated with a multi-pathogen recombinant SCV vaccine encoding the structural polyproteins of both Zika virus (ZIKV) and chikungunya virus (CHIKV). After one vaccination, neutralising antibody responses to ZIKV and four strains of CHIKV, representative of distinct viral genotypes, were generated. A second vaccination resulted in significant boosting of neutralising antibody responses to ZIKV and CHIKV. Following challenge with ZIKV, SCV-ZIKA/CHIK-vaccinated animals showed significant reductions in viremias compared with animals that had received a control SCV vaccine. Two SCV vaccinations also generated neutralising and IgG ELISA antibody responses to vaccinia virus. These results demonstrate effective induction of immunity in non-human primates by a recombinant SCV vaccine and illustrates the utility of SCV as a multi-disease vaccine platform capable of delivering multiple large immunogens.
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spelling pubmed-72654712020-06-16 The vaccinia virus based Sementis Copenhagen Vector vaccine against Zika and chikungunya is immunogenic in non-human primates Prow, Natalie A. Liu, Liang McCarthy, Mary K. Walters, Kevin Kalkeri, Raj Geiger, Jillian Koide, Fusataka Cooper, Tamara H. Eldi, Preethi Nakayama, Eri Diener, Kerrilyn R. Howley, Paul M. Hayball, John D. Morrison, Thomas E. Suhrbier, Andreas NPJ Vaccines Article The Sementis Copenhagen Vector (SCV) is a new vaccinia virus-derived, multiplication-defective, vaccine technology assessed herein in non-human primates. Indian rhesus macaques (Macaca mulatta) were vaccinated with a multi-pathogen recombinant SCV vaccine encoding the structural polyproteins of both Zika virus (ZIKV) and chikungunya virus (CHIKV). After one vaccination, neutralising antibody responses to ZIKV and four strains of CHIKV, representative of distinct viral genotypes, were generated. A second vaccination resulted in significant boosting of neutralising antibody responses to ZIKV and CHIKV. Following challenge with ZIKV, SCV-ZIKA/CHIK-vaccinated animals showed significant reductions in viremias compared with animals that had received a control SCV vaccine. Two SCV vaccinations also generated neutralising and IgG ELISA antibody responses to vaccinia virus. These results demonstrate effective induction of immunity in non-human primates by a recombinant SCV vaccine and illustrates the utility of SCV as a multi-disease vaccine platform capable of delivering multiple large immunogens. Nature Publishing Group UK 2020-06-02 /pmc/articles/PMC7265471/ /pubmed/32550013 http://dx.doi.org/10.1038/s41541-020-0191-8 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Prow, Natalie A.
Liu, Liang
McCarthy, Mary K.
Walters, Kevin
Kalkeri, Raj
Geiger, Jillian
Koide, Fusataka
Cooper, Tamara H.
Eldi, Preethi
Nakayama, Eri
Diener, Kerrilyn R.
Howley, Paul M.
Hayball, John D.
Morrison, Thomas E.
Suhrbier, Andreas
The vaccinia virus based Sementis Copenhagen Vector vaccine against Zika and chikungunya is immunogenic in non-human primates
title The vaccinia virus based Sementis Copenhagen Vector vaccine against Zika and chikungunya is immunogenic in non-human primates
title_full The vaccinia virus based Sementis Copenhagen Vector vaccine against Zika and chikungunya is immunogenic in non-human primates
title_fullStr The vaccinia virus based Sementis Copenhagen Vector vaccine against Zika and chikungunya is immunogenic in non-human primates
title_full_unstemmed The vaccinia virus based Sementis Copenhagen Vector vaccine against Zika and chikungunya is immunogenic in non-human primates
title_short The vaccinia virus based Sementis Copenhagen Vector vaccine against Zika and chikungunya is immunogenic in non-human primates
title_sort vaccinia virus based sementis copenhagen vector vaccine against zika and chikungunya is immunogenic in non-human primates
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265471/
https://www.ncbi.nlm.nih.gov/pubmed/32550013
http://dx.doi.org/10.1038/s41541-020-0191-8
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