Clinical features of familial clustering in patients infected with 2019 novel coronavirus in Wuhan, China

An epidemic caused by SARS-Coronavirus-2 (SARS-CoV-2) infection has appeared in Wuhan City in December 2019. The disease has shown a "clustering epidemic" pattern, and family-clustered onset has been the main characteristic. We collected data about 130 cases from 35 cluster-onset families...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Jinzhong, Gong, Xiaobing, Wang, Zhigang, Chen, Renzhou, Li, Taoyuan, Zeng, Dongyu, Li, Minran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265838/
https://www.ncbi.nlm.nih.gov/pubmed/32502551
http://dx.doi.org/10.1016/j.virusres.2020.198043
_version_ 1783541197320486912
author Li, Jinzhong
Gong, Xiaobing
Wang, Zhigang
Chen, Renzhou
Li, Taoyuan
Zeng, Dongyu
Li, Minran
author_facet Li, Jinzhong
Gong, Xiaobing
Wang, Zhigang
Chen, Renzhou
Li, Taoyuan
Zeng, Dongyu
Li, Minran
author_sort Li, Jinzhong
collection PubMed
description An epidemic caused by SARS-Coronavirus-2 (SARS-CoV-2) infection has appeared in Wuhan City in December 2019. The disease has shown a "clustering epidemic" pattern, and family-clustered onset has been the main characteristic. We collected data about 130 cases from 35 cluster-onset families (COFs) and 41 cases from 16 solitary-onset families (SOFs). The incidence of 2019 coronavirus disease (COVID-19) in COFs was significantly higher than that of SOFs. Our study also showed that patients with exposure to high-risk factors (respiratory droplets and close contact), advanced age, and comorbidities were more likely to develop COVID-19 in the COFs. In addition, advanced age and elevated neutrophil/lymphocyte ratio (NLR) were risk factors for death in patients with SARS-CoV-2 infection in the COFs.
format Online
Article
Text
id pubmed-7265838
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Elsevier B.V.
record_format MEDLINE/PubMed
spelling pubmed-72658382020-06-02 Clinical features of familial clustering in patients infected with 2019 novel coronavirus in Wuhan, China Li, Jinzhong Gong, Xiaobing Wang, Zhigang Chen, Renzhou Li, Taoyuan Zeng, Dongyu Li, Minran Virus Res Article An epidemic caused by SARS-Coronavirus-2 (SARS-CoV-2) infection has appeared in Wuhan City in December 2019. The disease has shown a "clustering epidemic" pattern, and family-clustered onset has been the main characteristic. We collected data about 130 cases from 35 cluster-onset families (COFs) and 41 cases from 16 solitary-onset families (SOFs). The incidence of 2019 coronavirus disease (COVID-19) in COFs was significantly higher than that of SOFs. Our study also showed that patients with exposure to high-risk factors (respiratory droplets and close contact), advanced age, and comorbidities were more likely to develop COVID-19 in the COFs. In addition, advanced age and elevated neutrophil/lymphocyte ratio (NLR) were risk factors for death in patients with SARS-CoV-2 infection in the COFs. Elsevier B.V. 2020-09 2020-06-02 /pmc/articles/PMC7265838/ /pubmed/32502551 http://dx.doi.org/10.1016/j.virusres.2020.198043 Text en © 2020 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Li, Jinzhong
Gong, Xiaobing
Wang, Zhigang
Chen, Renzhou
Li, Taoyuan
Zeng, Dongyu
Li, Minran
Clinical features of familial clustering in patients infected with 2019 novel coronavirus in Wuhan, China
title Clinical features of familial clustering in patients infected with 2019 novel coronavirus in Wuhan, China
title_full Clinical features of familial clustering in patients infected with 2019 novel coronavirus in Wuhan, China
title_fullStr Clinical features of familial clustering in patients infected with 2019 novel coronavirus in Wuhan, China
title_full_unstemmed Clinical features of familial clustering in patients infected with 2019 novel coronavirus in Wuhan, China
title_short Clinical features of familial clustering in patients infected with 2019 novel coronavirus in Wuhan, China
title_sort clinical features of familial clustering in patients infected with 2019 novel coronavirus in wuhan, china
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265838/
https://www.ncbi.nlm.nih.gov/pubmed/32502551
http://dx.doi.org/10.1016/j.virusres.2020.198043
work_keys_str_mv AT lijinzhong clinicalfeaturesoffamilialclusteringinpatientsinfectedwith2019novelcoronavirusinwuhanchina
AT gongxiaobing clinicalfeaturesoffamilialclusteringinpatientsinfectedwith2019novelcoronavirusinwuhanchina
AT wangzhigang clinicalfeaturesoffamilialclusteringinpatientsinfectedwith2019novelcoronavirusinwuhanchina
AT chenrenzhou clinicalfeaturesoffamilialclusteringinpatientsinfectedwith2019novelcoronavirusinwuhanchina
AT litaoyuan clinicalfeaturesoffamilialclusteringinpatientsinfectedwith2019novelcoronavirusinwuhanchina
AT zengdongyu clinicalfeaturesoffamilialclusteringinpatientsinfectedwith2019novelcoronavirusinwuhanchina
AT liminran clinicalfeaturesoffamilialclusteringinpatientsinfectedwith2019novelcoronavirusinwuhanchina

Ejemplares similares