SARS-CoV-2 infection: The role of cytokines in COVID-19 disease

COVID-19 disease, caused by infection with SARS-CoV-2, is related to a series of physiopathological mechanisms that mobilize a wide variety of biomolecules, mainly immunological in nature. In the most severe cases, the prognosis can be markedly worsened by the hyperproduction of mainly proinflammato...

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Autores principales: Costela-Ruiz, Víctor J., Illescas-Montes, Rebeca, Puerta-Puerta, Jose M., Ruiz, Concepción, Melguizo-Rodríguez, Lucia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265853/
https://www.ncbi.nlm.nih.gov/pubmed/32513566
http://dx.doi.org/10.1016/j.cytogfr.2020.06.001
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author Costela-Ruiz, Víctor J.
Illescas-Montes, Rebeca
Puerta-Puerta, Jose M.
Ruiz, Concepción
Melguizo-Rodríguez, Lucia
author_facet Costela-Ruiz, Víctor J.
Illescas-Montes, Rebeca
Puerta-Puerta, Jose M.
Ruiz, Concepción
Melguizo-Rodríguez, Lucia
author_sort Costela-Ruiz, Víctor J.
collection PubMed
description COVID-19 disease, caused by infection with SARS-CoV-2, is related to a series of physiopathological mechanisms that mobilize a wide variety of biomolecules, mainly immunological in nature. In the most severe cases, the prognosis can be markedly worsened by the hyperproduction of mainly proinflammatory cytokines, such as IL-1, IL-6, IL-12, IFN-γ, and TNF-α, preferentially targeting lung tissue. This study reviews published data on alterations in the expression of different cytokines in patients with COVID-19 who require admission to an intensive care unit. Data on the implication of cytokines in this disease and their effect on outcomes will support the design of more effective approaches to the management of COVID-19.
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spelling pubmed-72658532020-06-02 SARS-CoV-2 infection: The role of cytokines in COVID-19 disease Costela-Ruiz, Víctor J. Illescas-Montes, Rebeca Puerta-Puerta, Jose M. Ruiz, Concepción Melguizo-Rodríguez, Lucia Cytokine Growth Factor Rev Article COVID-19 disease, caused by infection with SARS-CoV-2, is related to a series of physiopathological mechanisms that mobilize a wide variety of biomolecules, mainly immunological in nature. In the most severe cases, the prognosis can be markedly worsened by the hyperproduction of mainly proinflammatory cytokines, such as IL-1, IL-6, IL-12, IFN-γ, and TNF-α, preferentially targeting lung tissue. This study reviews published data on alterations in the expression of different cytokines in patients with COVID-19 who require admission to an intensive care unit. Data on the implication of cytokines in this disease and their effect on outcomes will support the design of more effective approaches to the management of COVID-19. Elsevier Ltd. 2020-08 2020-06-02 /pmc/articles/PMC7265853/ /pubmed/32513566 http://dx.doi.org/10.1016/j.cytogfr.2020.06.001 Text en © 2020 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Costela-Ruiz, Víctor J.
Illescas-Montes, Rebeca
Puerta-Puerta, Jose M.
Ruiz, Concepción
Melguizo-Rodríguez, Lucia
SARS-CoV-2 infection: The role of cytokines in COVID-19 disease
title SARS-CoV-2 infection: The role of cytokines in COVID-19 disease
title_full SARS-CoV-2 infection: The role of cytokines in COVID-19 disease
title_fullStr SARS-CoV-2 infection: The role of cytokines in COVID-19 disease
title_full_unstemmed SARS-CoV-2 infection: The role of cytokines in COVID-19 disease
title_short SARS-CoV-2 infection: The role of cytokines in COVID-19 disease
title_sort sars-cov-2 infection: the role of cytokines in covid-19 disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265853/
https://www.ncbi.nlm.nih.gov/pubmed/32513566
http://dx.doi.org/10.1016/j.cytogfr.2020.06.001
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