The role of dual oxidases in physiology and cancer

NOX/DUOX enzymes are transmembrane proteins that carry electrons through biological membranes generating reactive oxygen species. The NOX family is composed of seven members, which are NOX1 to NOX5 and DUOX1 and 2. DUOX enzymes were initially called thyroid oxidases, based on their high expression l...

Descripción completa

Detalles Bibliográficos
Autores principales: de Faria, Caroline Coelho, Fortunato, Rodrigo Soares
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Genética 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265977/
https://www.ncbi.nlm.nih.gov/pubmed/32453337
http://dx.doi.org/10.1590/1678-4685/GMB-2019-0096
_version_ 1783541226567368704
author de Faria, Caroline Coelho
Fortunato, Rodrigo Soares
author_facet de Faria, Caroline Coelho
Fortunato, Rodrigo Soares
author_sort de Faria, Caroline Coelho
collection PubMed
description NOX/DUOX enzymes are transmembrane proteins that carry electrons through biological membranes generating reactive oxygen species. The NOX family is composed of seven members, which are NOX1 to NOX5 and DUOX1 and 2. DUOX enzymes were initially called thyroid oxidases, based on their high expression level in the thyroid tissue. However, DUOX expression has been documented in several extrathyroid tissues, mostly at the apical membrane of the salivary glands, the airways, and the intestinal tract, revealing additional cellular functions associated with DUOX-related H(2)O(2) generation. In this review, we will briefly summarize the current knowledge regarding DUOX structure and physiological functions, as well as their possible role in cancer biology.
format Online
Article
Text
id pubmed-7265977
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Sociedade Brasileira de Genética
record_format MEDLINE/PubMed
spelling pubmed-72659772020-06-10 The role of dual oxidases in physiology and cancer de Faria, Caroline Coelho Fortunato, Rodrigo Soares Genet Mol Biol Review Article NOX/DUOX enzymes are transmembrane proteins that carry electrons through biological membranes generating reactive oxygen species. The NOX family is composed of seven members, which are NOX1 to NOX5 and DUOX1 and 2. DUOX enzymes were initially called thyroid oxidases, based on their high expression level in the thyroid tissue. However, DUOX expression has been documented in several extrathyroid tissues, mostly at the apical membrane of the salivary glands, the airways, and the intestinal tract, revealing additional cellular functions associated with DUOX-related H(2)O(2) generation. In this review, we will briefly summarize the current knowledge regarding DUOX structure and physiological functions, as well as their possible role in cancer biology. Sociedade Brasileira de Genética 2020-05-20 /pmc/articles/PMC7265977/ /pubmed/32453337 http://dx.doi.org/10.1590/1678-4685/GMB-2019-0096 Text en https://creativecommons.org/licenses/by/4.0/ License information: This is an open-access article distributed under the terms of the Creative Commons Attribution License (type CC-BY), which permits unrestricted use, distribution and reproduction in any medium, provided the original article is properly cited.
spellingShingle Review Article
de Faria, Caroline Coelho
Fortunato, Rodrigo Soares
The role of dual oxidases in physiology and cancer
title The role of dual oxidases in physiology and cancer
title_full The role of dual oxidases in physiology and cancer
title_fullStr The role of dual oxidases in physiology and cancer
title_full_unstemmed The role of dual oxidases in physiology and cancer
title_short The role of dual oxidases in physiology and cancer
title_sort role of dual oxidases in physiology and cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265977/
https://www.ncbi.nlm.nih.gov/pubmed/32453337
http://dx.doi.org/10.1590/1678-4685/GMB-2019-0096
work_keys_str_mv AT defariacarolinecoelho theroleofdualoxidasesinphysiologyandcancer
AT fortunatorodrigosoares theroleofdualoxidasesinphysiologyandcancer
AT defariacarolinecoelho roleofdualoxidasesinphysiologyandcancer
AT fortunatorodrigosoares roleofdualoxidasesinphysiologyandcancer

Ejemplares similares