RAD52 S346X variant reduces breast cancer risk in BRCA2 mutation carriers

Adamson et al. report that BRCA2 mutation carriers inheriting RAD52 S346X variant have reduced breast cancer risk. The RAD52 S346X variant lacks the nuclear localization sequence, which mislocalizes the protein to the cytoplasm and renders it nonfunctional. Combined loss of BRCA2‐mediated DNA repair...

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Detalles Bibliográficos
Autores principales: Biswas, Kajal, Sharan, Shyam K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266267/
https://www.ncbi.nlm.nih.gov/pubmed/32255263
http://dx.doi.org/10.1002/1878-0261.12679
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author Biswas, Kajal
Sharan, Shyam K.
author_facet Biswas, Kajal
Sharan, Shyam K.
author_sort Biswas, Kajal
collection PubMed
description Adamson et al. report that BRCA2 mutation carriers inheriting RAD52 S346X variant have reduced breast cancer risk. The RAD52 S346X variant lacks the nuclear localization sequence, which mislocalizes the protein to the cytoplasm and renders it nonfunctional. Combined loss of BRCA2‐mediated DNA repair by homologous recombination and RAD52‐mediated single‐strand annealing may result in cell death and reduce breast cancer risk.[Image: see text] Comment on: https://doi.org/10.1002/1878-0261.12665
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spelling pubmed-72662672020-06-03 RAD52 S346X variant reduces breast cancer risk in BRCA2 mutation carriers Biswas, Kajal Sharan, Shyam K. Mol Oncol Commentary Adamson et al. report that BRCA2 mutation carriers inheriting RAD52 S346X variant have reduced breast cancer risk. The RAD52 S346X variant lacks the nuclear localization sequence, which mislocalizes the protein to the cytoplasm and renders it nonfunctional. Combined loss of BRCA2‐mediated DNA repair by homologous recombination and RAD52‐mediated single‐strand annealing may result in cell death and reduce breast cancer risk.[Image: see text] Comment on: https://doi.org/10.1002/1878-0261.12665 John Wiley and Sons Inc. 2020-04-21 2020-06 /pmc/articles/PMC7266267/ /pubmed/32255263 http://dx.doi.org/10.1002/1878-0261.12679 Text en Published 2020. This article is a U.S. Government work and is in the public domain in the USA. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Commentary
Biswas, Kajal
Sharan, Shyam K.
RAD52 S346X variant reduces breast cancer risk in BRCA2 mutation carriers
title RAD52 S346X variant reduces breast cancer risk in BRCA2 mutation carriers
title_full RAD52 S346X variant reduces breast cancer risk in BRCA2 mutation carriers
title_fullStr RAD52 S346X variant reduces breast cancer risk in BRCA2 mutation carriers
title_full_unstemmed RAD52 S346X variant reduces breast cancer risk in BRCA2 mutation carriers
title_short RAD52 S346X variant reduces breast cancer risk in BRCA2 mutation carriers
title_sort rad52 s346x variant reduces breast cancer risk in brca2 mutation carriers
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266267/
https://www.ncbi.nlm.nih.gov/pubmed/32255263
http://dx.doi.org/10.1002/1878-0261.12679
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