Targeting Hippo coactivator YAP1 through BET bromodomain inhibition in esophageal adenocarcinoma

Hippo/YAP1 signaling is a major regulator of organ size, cancer stemness, and aggressive phenotype. Thus, targeting YAP1 may provide a novel therapeutic strategy for tumors with high YAP1 expression in esophageal cancer (EC). Chromatin immunoprecipitation (ChiP) and quantitative ChiP‐PCR were used t...

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Detalles Bibliográficos
Autores principales: Song, Shumei, Li, Yuan, Xu, Yan, Ma, Lang, Pool Pizzi, Melissa, Jin, Jiankang, Scott, Ailing W, Huo, Longfei, Wang, Ying, Lee, Jeffrey H., Bhutani, Manoop S., Weston, Brian, Shanbhag, Namita D, Johnson, Randy L., Ajani, Jaffer A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266288/
https://www.ncbi.nlm.nih.gov/pubmed/32175692
http://dx.doi.org/10.1002/1878-0261.12667

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