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Accounting for long-range correlations in genome-wide simulations of large cohorts

Coalescent simulations are widely used to examine the effects of evolution and demographic history on the genetic makeup of populations. Thanks to recent progress in algorithms and data structures, simulators such as the widely-used msprime now provide genome-wide simulations for millions of individ...

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Detalles Bibliográficos
Autores principales: Nelson, Dominic, Kelleher, Jerome, Ragsdale, Aaron P., Moreau, Claudia, McVean, Gil, Gravel, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266353/
https://www.ncbi.nlm.nih.gov/pubmed/32369493
http://dx.doi.org/10.1371/journal.pgen.1008619

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