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Practical Considerations for Solid Organ Transplantation During the COVID-19 Global Outbreak: The Experience from Singapore

The current coronavirus disease 2019 (COVID-19) pandemic has not only caused global social disruptions but has also put tremendous strain on healthcare systems worldwide. With all attention and significant effort diverted to containing and managing the COVID-19 outbreak (and understandably so), esse...

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Autores principales: Chung, Shimin Jasmine, Tan, Ek Khoon, Kee, Terence, Krishnamoorthy, Thinesh Lee, Phua, Ghee Chee, Sewa, Duu Wen, Ong, Boon-Hean, Tan, Teing Ee, Sivathasan, Cumaraswamy, Gan, Huei Li Valerie, Goh, Brian Kim Poh, Jeyaraj, Prema Raj, Tan, Ban Hock
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266363/
https://www.ncbi.nlm.nih.gov/pubmed/32607420
http://dx.doi.org/10.1097/TXD.0000000000001002
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author Chung, Shimin Jasmine
Tan, Ek Khoon
Kee, Terence
Krishnamoorthy, Thinesh Lee
Phua, Ghee Chee
Sewa, Duu Wen
Ong, Boon-Hean
Tan, Teing Ee
Sivathasan, Cumaraswamy
Gan, Huei Li Valerie
Goh, Brian Kim Poh
Jeyaraj, Prema Raj
Tan, Ban Hock
author_facet Chung, Shimin Jasmine
Tan, Ek Khoon
Kee, Terence
Krishnamoorthy, Thinesh Lee
Phua, Ghee Chee
Sewa, Duu Wen
Ong, Boon-Hean
Tan, Teing Ee
Sivathasan, Cumaraswamy
Gan, Huei Li Valerie
Goh, Brian Kim Poh
Jeyaraj, Prema Raj
Tan, Ban Hock
author_sort Chung, Shimin Jasmine
collection PubMed
description The current coronavirus disease 2019 (COVID-19) pandemic has not only caused global social disruptions but has also put tremendous strain on healthcare systems worldwide. With all attention and significant effort diverted to containing and managing the COVID-19 outbreak (and understandably so), essential medical services such as transplant services are likely to be affected. Closure of transplant programs in an outbreak caused by a highly transmissible novel pathogen may be inevitable owing to patient safety. Yet program closure is not without harm; patients on the transplant waitlist may die before the program reopens. By adopting a tiered approach based on outbreak disease alert levels, and having hospital guidelines based on the best available evidence, life-saving transplants can still be safely performed. We performed a lung transplant and a liver transplant successfully during the COVID-19 era. We present our guidelines and experience on managing the transplant service as well as the selection and management of donors and recipients. We also discuss clinical dilemmas in the management COVID-19 in the posttransplant recipient.
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spelling pubmed-72663632020-06-29 Practical Considerations for Solid Organ Transplantation During the COVID-19 Global Outbreak: The Experience from Singapore Chung, Shimin Jasmine Tan, Ek Khoon Kee, Terence Krishnamoorthy, Thinesh Lee Phua, Ghee Chee Sewa, Duu Wen Ong, Boon-Hean Tan, Teing Ee Sivathasan, Cumaraswamy Gan, Huei Li Valerie Goh, Brian Kim Poh Jeyaraj, Prema Raj Tan, Ban Hock Transplant Direct Review The current coronavirus disease 2019 (COVID-19) pandemic has not only caused global social disruptions but has also put tremendous strain on healthcare systems worldwide. With all attention and significant effort diverted to containing and managing the COVID-19 outbreak (and understandably so), essential medical services such as transplant services are likely to be affected. Closure of transplant programs in an outbreak caused by a highly transmissible novel pathogen may be inevitable owing to patient safety. Yet program closure is not without harm; patients on the transplant waitlist may die before the program reopens. By adopting a tiered approach based on outbreak disease alert levels, and having hospital guidelines based on the best available evidence, life-saving transplants can still be safely performed. We performed a lung transplant and a liver transplant successfully during the COVID-19 era. We present our guidelines and experience on managing the transplant service as well as the selection and management of donors and recipients. We also discuss clinical dilemmas in the management COVID-19 in the posttransplant recipient. Wolters Kluwer Health 2020-05-08 /pmc/articles/PMC7266363/ /pubmed/32607420 http://dx.doi.org/10.1097/TXD.0000000000001002 Text en Copyright © 2020 The Author(s). Transplantation Direct. Published by Wolters Kluwer Health, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Review
Chung, Shimin Jasmine
Tan, Ek Khoon
Kee, Terence
Krishnamoorthy, Thinesh Lee
Phua, Ghee Chee
Sewa, Duu Wen
Ong, Boon-Hean
Tan, Teing Ee
Sivathasan, Cumaraswamy
Gan, Huei Li Valerie
Goh, Brian Kim Poh
Jeyaraj, Prema Raj
Tan, Ban Hock
Practical Considerations for Solid Organ Transplantation During the COVID-19 Global Outbreak: The Experience from Singapore
title Practical Considerations for Solid Organ Transplantation During the COVID-19 Global Outbreak: The Experience from Singapore
title_full Practical Considerations for Solid Organ Transplantation During the COVID-19 Global Outbreak: The Experience from Singapore
title_fullStr Practical Considerations for Solid Organ Transplantation During the COVID-19 Global Outbreak: The Experience from Singapore
title_full_unstemmed Practical Considerations for Solid Organ Transplantation During the COVID-19 Global Outbreak: The Experience from Singapore
title_short Practical Considerations for Solid Organ Transplantation During the COVID-19 Global Outbreak: The Experience from Singapore
title_sort practical considerations for solid organ transplantation during the covid-19 global outbreak: the experience from singapore
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266363/
https://www.ncbi.nlm.nih.gov/pubmed/32607420
http://dx.doi.org/10.1097/TXD.0000000000001002
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