Cargando…
Asymptomatic carriage and transmission of SARS-CoV-2: What do we know?
PURPOSE: Risk to healthcare workers treating asymptomatic patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the operating room depends on multiple factors. This review examines the evidence for asymptomatic or pre-symptomatic carriage of SARS-CoV-2, the risk of t...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266417/ https://www.ncbi.nlm.nih.gov/pubmed/32488493 http://dx.doi.org/10.1007/s12630-020-01729-x |
_version_ | 1783541304921161728 |
---|---|
author | Lee, Susan Meyler, Paula Mozel, Michelle Tauh, Tonia Merchant, Richard |
author_facet | Lee, Susan Meyler, Paula Mozel, Michelle Tauh, Tonia Merchant, Richard |
author_sort | Lee, Susan |
collection | PubMed |
description | PURPOSE: Risk to healthcare workers treating asymptomatic patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the operating room depends on multiple factors. This review examines the evidence for asymptomatic or pre-symptomatic carriage of SARS-CoV-2, the risk of transmission from asymptomatic patients, and the specific risks associated with aerosol-generating procedures. Protective measures, such as minimization of aerosols and use of personal protective equipment in the setting of treating asymptomatic patients, are also reviewed. SOURCE: We examined the published literature as well as Societal guidelines. PRINCIPAL FINDINGS: There is evidence that a proportion of those infected with SARS-CoV-2 have detectable viral loads prior to exhibiting symptoms, or without ever developing symptoms. The degree of risk of transmission from asymptomatic patients to healthcare providers will depend on the prevalence of disease in the population, which is difficult to assess without widespread population screening. Aerosol-generating procedures increase the odds of viral transmission from infected symptomatic patients to healthcare providers, but transmission from asymptomatic patients has not been reported. Techniques to minimize aerosolization and appropriate personal protective equipment may help reduce the risk to healthcare workers in the operating room. Some societal guidelines recommend the use of airborne precautions during aerosol-generating procedures on asymptomatic patients during the coronavirus disease pandemic, although evidence supporting this practice is limited. CONCLUSION: Viral transmission from patients exhibiting no symptoms in the operating room is plausible and efforts to reduce risk to healthcare providers include reducing aerosolization and wearing appropriate personal protective equipment, the feasibility of which will vary based on geographic risk and equipment availability. |
format | Online Article Text |
id | pubmed-7266417 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-72664172020-06-03 Asymptomatic carriage and transmission of SARS-CoV-2: What do we know? Lee, Susan Meyler, Paula Mozel, Michelle Tauh, Tonia Merchant, Richard Can J Anaesth Review Article/Brief Review PURPOSE: Risk to healthcare workers treating asymptomatic patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the operating room depends on multiple factors. This review examines the evidence for asymptomatic or pre-symptomatic carriage of SARS-CoV-2, the risk of transmission from asymptomatic patients, and the specific risks associated with aerosol-generating procedures. Protective measures, such as minimization of aerosols and use of personal protective equipment in the setting of treating asymptomatic patients, are also reviewed. SOURCE: We examined the published literature as well as Societal guidelines. PRINCIPAL FINDINGS: There is evidence that a proportion of those infected with SARS-CoV-2 have detectable viral loads prior to exhibiting symptoms, or without ever developing symptoms. The degree of risk of transmission from asymptomatic patients to healthcare providers will depend on the prevalence of disease in the population, which is difficult to assess without widespread population screening. Aerosol-generating procedures increase the odds of viral transmission from infected symptomatic patients to healthcare providers, but transmission from asymptomatic patients has not been reported. Techniques to minimize aerosolization and appropriate personal protective equipment may help reduce the risk to healthcare workers in the operating room. Some societal guidelines recommend the use of airborne precautions during aerosol-generating procedures on asymptomatic patients during the coronavirus disease pandemic, although evidence supporting this practice is limited. CONCLUSION: Viral transmission from patients exhibiting no symptoms in the operating room is plausible and efforts to reduce risk to healthcare providers include reducing aerosolization and wearing appropriate personal protective equipment, the feasibility of which will vary based on geographic risk and equipment availability. Springer International Publishing 2020-06-02 2020 /pmc/articles/PMC7266417/ /pubmed/32488493 http://dx.doi.org/10.1007/s12630-020-01729-x Text en © Canadian Anesthesiologists' Society 2020, Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Review Article/Brief Review Lee, Susan Meyler, Paula Mozel, Michelle Tauh, Tonia Merchant, Richard Asymptomatic carriage and transmission of SARS-CoV-2: What do we know? |
title | Asymptomatic carriage and transmission of SARS-CoV-2: What do we know? |
title_full | Asymptomatic carriage and transmission of SARS-CoV-2: What do we know? |
title_fullStr | Asymptomatic carriage and transmission of SARS-CoV-2: What do we know? |
title_full_unstemmed | Asymptomatic carriage and transmission of SARS-CoV-2: What do we know? |
title_short | Asymptomatic carriage and transmission of SARS-CoV-2: What do we know? |
title_sort | asymptomatic carriage and transmission of sars-cov-2: what do we know? |
topic | Review Article/Brief Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266417/ https://www.ncbi.nlm.nih.gov/pubmed/32488493 http://dx.doi.org/10.1007/s12630-020-01729-x |
work_keys_str_mv | AT leesusan asymptomaticcarriageandtransmissionofsarscov2whatdoweknow AT meylerpaula asymptomaticcarriageandtransmissionofsarscov2whatdoweknow AT mozelmichelle asymptomaticcarriageandtransmissionofsarscov2whatdoweknow AT tauhtonia asymptomaticcarriageandtransmissionofsarscov2whatdoweknow AT merchantrichard asymptomaticcarriageandtransmissionofsarscov2whatdoweknow |