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A Comprehensive Review of Severe Acute Respiratory Syndrome Coronavirus 2
Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), the virus strain that causes coronavirus disease 2019 (COVID-19), was first identified in Wuhan, China in December 2019. It spread to several countries across continents and infected more than one million people within three months. While...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Cureus
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266564/ https://www.ncbi.nlm.nih.gov/pubmed/32499983 http://dx.doi.org/10.7759/cureus.7943 |
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author | Baek, Woong Kee Sohn, Soo-Yeon Mahgoub, Ahmed Hage, Robert |
author_facet | Baek, Woong Kee Sohn, Soo-Yeon Mahgoub, Ahmed Hage, Robert |
author_sort | Baek, Woong Kee |
collection | PubMed |
description | Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), the virus strain that causes coronavirus disease 2019 (COVID-19), was first identified in Wuhan, China in December 2019. It spread to several countries across continents and infected more than one million people within three months. While there is no consensus on the treatment of the disease yet, understanding the virus and its transmission is a cardinal priority. SARS-CoV-2 can be transmitted through bodily fluid. Upon inoculation, the surface enzyme angiotensin-converting enzyme 2 (ACE2) acts as a receptor protein for viral entry. The mean incubation period is 5.1 days, and infected individuals can exhibit a variety of symptoms from fever, cough, dyspnea, and respiratory failure to even multiorgan failure. Given the current situation, it is of paramount importance to understand the virus as thoroughly as possible. In this review, we discuss the background, epidemiology, possible pathophysiology, clinical presentation, and diagnostic studies related to SARS-CoV-2 infection. We also elaborate on the current research and evidence on treatment options and vaccine development based on the literature. |
format | Online Article Text |
id | pubmed-7266564 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-72665642020-06-03 A Comprehensive Review of Severe Acute Respiratory Syndrome Coronavirus 2 Baek, Woong Kee Sohn, Soo-Yeon Mahgoub, Ahmed Hage, Robert Cureus Internal Medicine Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), the virus strain that causes coronavirus disease 2019 (COVID-19), was first identified in Wuhan, China in December 2019. It spread to several countries across continents and infected more than one million people within three months. While there is no consensus on the treatment of the disease yet, understanding the virus and its transmission is a cardinal priority. SARS-CoV-2 can be transmitted through bodily fluid. Upon inoculation, the surface enzyme angiotensin-converting enzyme 2 (ACE2) acts as a receptor protein for viral entry. The mean incubation period is 5.1 days, and infected individuals can exhibit a variety of symptoms from fever, cough, dyspnea, and respiratory failure to even multiorgan failure. Given the current situation, it is of paramount importance to understand the virus as thoroughly as possible. In this review, we discuss the background, epidemiology, possible pathophysiology, clinical presentation, and diagnostic studies related to SARS-CoV-2 infection. We also elaborate on the current research and evidence on treatment options and vaccine development based on the literature. Cureus 2020-05-03 /pmc/articles/PMC7266564/ /pubmed/32499983 http://dx.doi.org/10.7759/cureus.7943 Text en Copyright © 2020, Baek et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Internal Medicine Baek, Woong Kee Sohn, Soo-Yeon Mahgoub, Ahmed Hage, Robert A Comprehensive Review of Severe Acute Respiratory Syndrome Coronavirus 2 |
title | A Comprehensive Review of Severe Acute Respiratory Syndrome Coronavirus 2 |
title_full | A Comprehensive Review of Severe Acute Respiratory Syndrome Coronavirus 2 |
title_fullStr | A Comprehensive Review of Severe Acute Respiratory Syndrome Coronavirus 2 |
title_full_unstemmed | A Comprehensive Review of Severe Acute Respiratory Syndrome Coronavirus 2 |
title_short | A Comprehensive Review of Severe Acute Respiratory Syndrome Coronavirus 2 |
title_sort | comprehensive review of severe acute respiratory syndrome coronavirus 2 |
topic | Internal Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266564/ https://www.ncbi.nlm.nih.gov/pubmed/32499983 http://dx.doi.org/10.7759/cureus.7943 |
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