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Replicability of structural brain alterations associated with general psychopathology: evidence from a population-representative birth cohort
Transdiagnostic research has identified a general psychopathology factor—often called the ‘p’ factor—that accounts for shared variation across internalizing, externalizing, and thought disorders in diverse samples. It has been argued that the p factor may reflect dysfunctional thinking present in se...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266702/ https://www.ncbi.nlm.nih.gov/pubmed/31796893 http://dx.doi.org/10.1038/s41380-019-0621-z |
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author | Romer, Adrienne L. Knodt, Annchen R. Sison, Maria L. Ireland, David Houts, Renate Ramrakha, Sandhya Poulton, Richie Keenan, Ross Melzer, Tracy R. Moffitt, Terrie E. Caspi, Avshalom Hariri, Ahmad R. |
author_facet | Romer, Adrienne L. Knodt, Annchen R. Sison, Maria L. Ireland, David Houts, Renate Ramrakha, Sandhya Poulton, Richie Keenan, Ross Melzer, Tracy R. Moffitt, Terrie E. Caspi, Avshalom Hariri, Ahmad R. |
author_sort | Romer, Adrienne L. |
collection | PubMed |
description | Transdiagnostic research has identified a general psychopathology factor—often called the ‘p’ factor—that accounts for shared variation across internalizing, externalizing, and thought disorders in diverse samples. It has been argued that the p factor may reflect dysfunctional thinking present in serious mental illness. In support of this, we previously used a theory-free, data-driven multimodal neuroimaging approach to find that higher p factor scores are associated with structural alterations within a cerebello-thalamo-cortical circuit (CTCC) and visual association cortex, both of which are important for monitoring and coordinating information processing in the service of executive control. Here we attempt to replicate these associations by conducting region-of-interest analyses using data from 875 members of the Dunedin Longitudinal Study, a five-decade study of a population-representative birth cohort, collected when they were 45 years old. We further sought to replicate a more recent report that p factor scores can be predicted by patterns of distributed cerebellar morphology as estimated through independent component analysis. We successfully replicated associations between higher p factor scores and both reduced gray matter volume of the visual association cortex and fractional anisotropy of pontine white matter pathways within the CTCC. In contrast, we failed to replicate prior associations between cerebellar structure and p factor scores. Collectively, our findings encourage further focus on the CTCC and visual association cortex as core neural substrates and potential biomarkers of general psychopathology. |
format | Online Article Text |
id | pubmed-7266702 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-72667022021-06-03 Replicability of structural brain alterations associated with general psychopathology: evidence from a population-representative birth cohort Romer, Adrienne L. Knodt, Annchen R. Sison, Maria L. Ireland, David Houts, Renate Ramrakha, Sandhya Poulton, Richie Keenan, Ross Melzer, Tracy R. Moffitt, Terrie E. Caspi, Avshalom Hariri, Ahmad R. Mol Psychiatry Article Transdiagnostic research has identified a general psychopathology factor—often called the ‘p’ factor—that accounts for shared variation across internalizing, externalizing, and thought disorders in diverse samples. It has been argued that the p factor may reflect dysfunctional thinking present in serious mental illness. In support of this, we previously used a theory-free, data-driven multimodal neuroimaging approach to find that higher p factor scores are associated with structural alterations within a cerebello-thalamo-cortical circuit (CTCC) and visual association cortex, both of which are important for monitoring and coordinating information processing in the service of executive control. Here we attempt to replicate these associations by conducting region-of-interest analyses using data from 875 members of the Dunedin Longitudinal Study, a five-decade study of a population-representative birth cohort, collected when they were 45 years old. We further sought to replicate a more recent report that p factor scores can be predicted by patterns of distributed cerebellar morphology as estimated through independent component analysis. We successfully replicated associations between higher p factor scores and both reduced gray matter volume of the visual association cortex and fractional anisotropy of pontine white matter pathways within the CTCC. In contrast, we failed to replicate prior associations between cerebellar structure and p factor scores. Collectively, our findings encourage further focus on the CTCC and visual association cortex as core neural substrates and potential biomarkers of general psychopathology. Nature Publishing Group UK 2019-12-03 2021 /pmc/articles/PMC7266702/ /pubmed/31796893 http://dx.doi.org/10.1038/s41380-019-0621-z Text en © The Author(s) 2019 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Romer, Adrienne L. Knodt, Annchen R. Sison, Maria L. Ireland, David Houts, Renate Ramrakha, Sandhya Poulton, Richie Keenan, Ross Melzer, Tracy R. Moffitt, Terrie E. Caspi, Avshalom Hariri, Ahmad R. Replicability of structural brain alterations associated with general psychopathology: evidence from a population-representative birth cohort |
title | Replicability of structural brain alterations associated with general psychopathology: evidence from a population-representative birth cohort |
title_full | Replicability of structural brain alterations associated with general psychopathology: evidence from a population-representative birth cohort |
title_fullStr | Replicability of structural brain alterations associated with general psychopathology: evidence from a population-representative birth cohort |
title_full_unstemmed | Replicability of structural brain alterations associated with general psychopathology: evidence from a population-representative birth cohort |
title_short | Replicability of structural brain alterations associated with general psychopathology: evidence from a population-representative birth cohort |
title_sort | replicability of structural brain alterations associated with general psychopathology: evidence from a population-representative birth cohort |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266702/ https://www.ncbi.nlm.nih.gov/pubmed/31796893 http://dx.doi.org/10.1038/s41380-019-0621-z |
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