The Nlrp3 inflammasome as a “rising star” in studies of normal and malignant hematopoiesis

Recent investigations indicate that hematopoiesis is coregulated by innate immunity signals and by pathways characteristic of the activation of innate immunity cells that also operate in normal hematopoietic stem progenitor cells (HSPCs). This should not be surprising because of the common developme...

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Autores principales: Ratajczak, Mariusz Z., Bujko, Kamila, Cymer, Monika, Thapa, Arjun, Adamiak, Mateusz, Ratajczak, Janina, Abdel-Latif, Ahmed K., Kucia, Magda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266743/
https://www.ncbi.nlm.nih.gov/pubmed/32313108
http://dx.doi.org/10.1038/s41375-020-0827-8
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author Ratajczak, Mariusz Z.
Bujko, Kamila
Cymer, Monika
Thapa, Arjun
Adamiak, Mateusz
Ratajczak, Janina
Abdel-Latif, Ahmed K.
Kucia, Magda
author_facet Ratajczak, Mariusz Z.
Bujko, Kamila
Cymer, Monika
Thapa, Arjun
Adamiak, Mateusz
Ratajczak, Janina
Abdel-Latif, Ahmed K.
Kucia, Magda
author_sort Ratajczak, Mariusz Z.
collection PubMed
description Recent investigations indicate that hematopoiesis is coregulated by innate immunity signals and by pathways characteristic of the activation of innate immunity cells that also operate in normal hematopoietic stem progenitor cells (HSPCs). This should not be surprising because of the common developmental origin of these cells from a hemato/lymphopoietic stem cell. An important integrating factor is the Nlrp3 inflammasome, which has emerged as a major sensor of changes in body microenvironments, cell activation, and cell metabolic activity. It is currently the best-studied member of the inflammasome family expressed in hematopoietic and lymphopoietic cells, including also HSPCs. It is proposed as playing a role in (i) the development and expansion of HSPCs, (ii) their release from bone marrow (BM) into peripheral blood (PB) in stress situations and during pharmacological mobilization, (iii) their homing to BM after transplantation, and (iv) their aging and the regulation of hematopoietic cell metabolism. The Nlrp3 inflammasome is also involved in certain hematological pathologies, including (i) myelodysplastic syndrome, (ii) myeloproliferative neoplasms, (iii) leukemia, and (iv) graft-versus-host disease (GvHD) after transplantation. The aim of this review is to shed more light on this intriguing intracellular protein complex that has become a “rising star” in studies focused on both normal steady-state and pathological hematopoiesis.
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spelling pubmed-72667432020-06-15 The Nlrp3 inflammasome as a “rising star” in studies of normal and malignant hematopoiesis Ratajczak, Mariusz Z. Bujko, Kamila Cymer, Monika Thapa, Arjun Adamiak, Mateusz Ratajczak, Janina Abdel-Latif, Ahmed K. Kucia, Magda Leukemia Review Article Recent investigations indicate that hematopoiesis is coregulated by innate immunity signals and by pathways characteristic of the activation of innate immunity cells that also operate in normal hematopoietic stem progenitor cells (HSPCs). This should not be surprising because of the common developmental origin of these cells from a hemato/lymphopoietic stem cell. An important integrating factor is the Nlrp3 inflammasome, which has emerged as a major sensor of changes in body microenvironments, cell activation, and cell metabolic activity. It is currently the best-studied member of the inflammasome family expressed in hematopoietic and lymphopoietic cells, including also HSPCs. It is proposed as playing a role in (i) the development and expansion of HSPCs, (ii) their release from bone marrow (BM) into peripheral blood (PB) in stress situations and during pharmacological mobilization, (iii) their homing to BM after transplantation, and (iv) their aging and the regulation of hematopoietic cell metabolism. The Nlrp3 inflammasome is also involved in certain hematological pathologies, including (i) myelodysplastic syndrome, (ii) myeloproliferative neoplasms, (iii) leukemia, and (iv) graft-versus-host disease (GvHD) after transplantation. The aim of this review is to shed more light on this intriguing intracellular protein complex that has become a “rising star” in studies focused on both normal steady-state and pathological hematopoiesis. Nature Publishing Group UK 2020-04-20 2020 /pmc/articles/PMC7266743/ /pubmed/32313108 http://dx.doi.org/10.1038/s41375-020-0827-8 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
Ratajczak, Mariusz Z.
Bujko, Kamila
Cymer, Monika
Thapa, Arjun
Adamiak, Mateusz
Ratajczak, Janina
Abdel-Latif, Ahmed K.
Kucia, Magda
The Nlrp3 inflammasome as a “rising star” in studies of normal and malignant hematopoiesis
title The Nlrp3 inflammasome as a “rising star” in studies of normal and malignant hematopoiesis
title_full The Nlrp3 inflammasome as a “rising star” in studies of normal and malignant hematopoiesis
title_fullStr The Nlrp3 inflammasome as a “rising star” in studies of normal and malignant hematopoiesis
title_full_unstemmed The Nlrp3 inflammasome as a “rising star” in studies of normal and malignant hematopoiesis
title_short The Nlrp3 inflammasome as a “rising star” in studies of normal and malignant hematopoiesis
title_sort nlrp3 inflammasome as a “rising star” in studies of normal and malignant hematopoiesis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266743/
https://www.ncbi.nlm.nih.gov/pubmed/32313108
http://dx.doi.org/10.1038/s41375-020-0827-8
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