CRISPR/Cas9-generated models uncover therapeutic vulnerabilities of del(11q) CLL cells to dual BCR and PARP inhibition

The deletion of 11q (del(11q)) invariably comprises ATM gene in chronic lymphocytic leukemia (CLL). Concomitant mutations in this gene in the remaining allele have been identified in 1/3 of CLL cases harboring del(11q), being the biallelic loss of ATM associated with adverse prognosis. Although the...

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Detalles Bibliográficos
Autores principales: Quijada-Álamo, Miguel, Hernández-Sánchez, María, Alonso-Pérez, Verónica, Rodríguez-Vicente, Ana E., García-Tuñón, Ignacio, Martín-Izquierdo, Marta, Hernández-Sánchez, Jesús María, Herrero, Ana B., Bastida, José María, San Segundo, Laura, Gruber, Michaela, García, Juan Luis, Yin, Shanye, ten Hacken, Elisa, Benito, Rocío, Ordóñez, José Luis, Wu, Catherine J., Hernández-Rivas, Jesús María
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266745/
https://www.ncbi.nlm.nih.gov/pubmed/31974435
http://dx.doi.org/10.1038/s41375-020-0714-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266745/
https://www.ncbi.nlm.nih.gov/pubmed/31974435
http://dx.doi.org/10.1038/s41375-020-0714-3

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