Constitutive TSH receptor activation as a hallmark of thyroid autonomy

Since its cloning more than 30 years ago, the thyrotropin receptor (TSHR) has emerged as a pivotal player in thyroid physiology and pathophysiology. In particular, hyperthyroidism due to autoimmune disease or thyroid autonomy is linked with TSHR activation via autoantibodies or mutations respectivel...

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Detalles Bibliográficos
Autor principal: Führer, Dagmar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Mini Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266789/
https://www.ncbi.nlm.nih.gov/pubmed/32303903
http://dx.doi.org/10.1007/s12020-020-02270-z
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author Führer, Dagmar
author_facet Führer, Dagmar
author_sort Führer, Dagmar
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description Since its cloning more than 30 years ago, the thyrotropin receptor (TSHR) has emerged as a pivotal player in thyroid physiology and pathophysiology. In particular, hyperthyroidism due to autoimmune disease or thyroid autonomy is linked with TSHR activation via autoantibodies or mutations respectively. This review summarises clinical aspects of constitutive TSH receptor activation by naturally occurring somatic or germline TSHR mutations resulting in TSH-independent thyroid function and cell proliferation.
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spelling pubmed-72667892020-06-12 Constitutive TSH receptor activation as a hallmark of thyroid autonomy Führer, Dagmar Endocrine Mini Review Since its cloning more than 30 years ago, the thyrotropin receptor (TSHR) has emerged as a pivotal player in thyroid physiology and pathophysiology. In particular, hyperthyroidism due to autoimmune disease or thyroid autonomy is linked with TSHR activation via autoantibodies or mutations respectively. This review summarises clinical aspects of constitutive TSH receptor activation by naturally occurring somatic or germline TSHR mutations resulting in TSH-independent thyroid function and cell proliferation. Springer US 2020-04-17 2020 /pmc/articles/PMC7266789/ /pubmed/32303903 http://dx.doi.org/10.1007/s12020-020-02270-z Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Mini Review
Führer, Dagmar
Constitutive TSH receptor activation as a hallmark of thyroid autonomy
title Constitutive TSH receptor activation as a hallmark of thyroid autonomy
title_full Constitutive TSH receptor activation as a hallmark of thyroid autonomy
title_fullStr Constitutive TSH receptor activation as a hallmark of thyroid autonomy
title_full_unstemmed Constitutive TSH receptor activation as a hallmark of thyroid autonomy
title_short Constitutive TSH receptor activation as a hallmark of thyroid autonomy
title_sort constitutive tsh receptor activation as a hallmark of thyroid autonomy
topic Mini Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266789/
https://www.ncbi.nlm.nih.gov/pubmed/32303903
http://dx.doi.org/10.1007/s12020-020-02270-z
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