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Bioequivalence of a Newly Developed Dabigatran Etexilate Tablet Versus the Commercial Capsule and Impact of Rabeprazole-Induced Elevated Gastric pH on Exposure in Healthy Subjects

BACKGROUND AND OBJECTIVE: Dabigatran etexilate (DE) is an anticoagulant with proven efficacy and tolerability for stroke prevention in patients with non-valvular atrial fibrillation. For the commercial capsule, a complex formulation is used to maintain the acidic microenvironment required for maxima...

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Detalles Bibliográficos
Autores principales:	Harada, Akiko, Ikushima, Ippei, Haranaka, Miwa, Yanagihara, Aki, Nakayama, Daisuke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2019
Materias:	Original Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266796/ https://www.ncbi.nlm.nih.gov/pubmed/31667735 http://dx.doi.org/10.1007/s40256-019-00377-x

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