Chitosan-capped enzyme-responsive hollow mesoporous silica nanoplatforms for colon-specific drug delivery

An enzyme-responsive colon-specific delivery system was developed based on hollow mesoporous silica spheres (HMSS) to which biodegradable chitosan (CS) was attached via cleavable azo bonds (HMSS–N=N–CS). Doxorubicin (DOX) was encapsulated in a noncrystalline state in the hollow cavity and mesopores...

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Detalles Bibliográficos
Autores principales: Cai, Defu, Han, Cuiyan, Liu, Chang, Ma, Xiaoxing, Qian, Jiayi, Zhou, Jianwen, Li, Yue, Sun, Yiming, Zhang, Changting, Zhu, Wenquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Nano Express
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266918/
https://www.ncbi.nlm.nih.gov/pubmed/32488526
http://dx.doi.org/10.1186/s11671-020-03351-8

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