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Circular RNAs in Embryogenesis and Cell Differentiation With a Focus on Cancer Development
In the recent years thousands of non-coding RNAs have been identified, also thanks to highthroughput sequencing technologies. Among them, circular RNAs (circRNAs) are a well-represented class characterized by the high sequence conservation and cell type specific expression in eukaryotes. They are co...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266935/ https://www.ncbi.nlm.nih.gov/pubmed/32528957 http://dx.doi.org/10.3389/fcell.2020.00389 |
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author | Di Agostino, Silvia Riccioli, Anna De Cesaris, Paola Fontemaggi, Giulia Blandino, Giovanni Filippini, Antonio Fazi, Francesco |
author_facet | Di Agostino, Silvia Riccioli, Anna De Cesaris, Paola Fontemaggi, Giulia Blandino, Giovanni Filippini, Antonio Fazi, Francesco |
author_sort | Di Agostino, Silvia |
collection | PubMed |
description | In the recent years thousands of non-coding RNAs have been identified, also thanks to highthroughput sequencing technologies. Among them, circular RNAs (circRNAs) are a well-represented class characterized by the high sequence conservation and cell type specific expression in eukaryotes. They are covalently closed loops formed through back-splicing. Recently, circRNAs were shown to regulate a variety of cellular processes functioning as miRNA sponges, RBP binding molecules, transcriptional regulators, scaffold for protein translation, as well as immune regulators. A growing number of studies are showing that deregulated expression of circRNAs plays important and decisive actions during the development of several human diseases, including cancer. The research on their biogenesis and on the various molecular mechanisms in which they are involved is going very fast, however, there are still few studies that address their involvement in embryogenesis and eukaryotic development. This review has the intent to describe the most recent progress in the study of the biogenesis and molecular activities of circRNAs providing insightful information in the field of embryogenesis and cell differentiation. In addition, we describe the latest research on circRNAs as novel promising biomarkers in diverse types of tumors. |
format | Online Article Text |
id | pubmed-7266935 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-72669352020-06-10 Circular RNAs in Embryogenesis and Cell Differentiation With a Focus on Cancer Development Di Agostino, Silvia Riccioli, Anna De Cesaris, Paola Fontemaggi, Giulia Blandino, Giovanni Filippini, Antonio Fazi, Francesco Front Cell Dev Biol Cell and Developmental Biology In the recent years thousands of non-coding RNAs have been identified, also thanks to highthroughput sequencing technologies. Among them, circular RNAs (circRNAs) are a well-represented class characterized by the high sequence conservation and cell type specific expression in eukaryotes. They are covalently closed loops formed through back-splicing. Recently, circRNAs were shown to regulate a variety of cellular processes functioning as miRNA sponges, RBP binding molecules, transcriptional regulators, scaffold for protein translation, as well as immune regulators. A growing number of studies are showing that deregulated expression of circRNAs plays important and decisive actions during the development of several human diseases, including cancer. The research on their biogenesis and on the various molecular mechanisms in which they are involved is going very fast, however, there are still few studies that address their involvement in embryogenesis and eukaryotic development. This review has the intent to describe the most recent progress in the study of the biogenesis and molecular activities of circRNAs providing insightful information in the field of embryogenesis and cell differentiation. In addition, we describe the latest research on circRNAs as novel promising biomarkers in diverse types of tumors. Frontiers Media S.A. 2020-05-27 /pmc/articles/PMC7266935/ /pubmed/32528957 http://dx.doi.org/10.3389/fcell.2020.00389 Text en Copyright © 2020 Di Agostino, Riccioli, De Cesaris, Fontemaggi, Blandino, Filippini and Fazi. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Di Agostino, Silvia Riccioli, Anna De Cesaris, Paola Fontemaggi, Giulia Blandino, Giovanni Filippini, Antonio Fazi, Francesco Circular RNAs in Embryogenesis and Cell Differentiation With a Focus on Cancer Development |
title | Circular RNAs in Embryogenesis and Cell Differentiation With a Focus on Cancer Development |
title_full | Circular RNAs in Embryogenesis and Cell Differentiation With a Focus on Cancer Development |
title_fullStr | Circular RNAs in Embryogenesis and Cell Differentiation With a Focus on Cancer Development |
title_full_unstemmed | Circular RNAs in Embryogenesis and Cell Differentiation With a Focus on Cancer Development |
title_short | Circular RNAs in Embryogenesis and Cell Differentiation With a Focus on Cancer Development |
title_sort | circular rnas in embryogenesis and cell differentiation with a focus on cancer development |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266935/ https://www.ncbi.nlm.nih.gov/pubmed/32528957 http://dx.doi.org/10.3389/fcell.2020.00389 |
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