Structural basis of HapE(P88L)-linked antifungal triazole resistance in Aspergillus fumigatus

Azoles are first-line therapeutics for human and plant fungal infections, but their broad use has promoted the development of resistances. Recently, a pan-azole–resistant clinical Aspergillus fumigatus isolate was identified to carry the mutation P88L in subunit HapE of the CCAAT-binding complex (CB...

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Detalles Bibliográficos
Autores principales: Hortschansky, Peter, Misslinger, Matthias, Mörl, Jasmin, Gsaller, Fabio, Bromley, Michael J, Brakhage, Axel A, Groll, Michael, Haas, Hubertus, Huber, Eva M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266990/
https://www.ncbi.nlm.nih.gov/pubmed/32467317
http://dx.doi.org/10.26508/lsa.202000729

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266990/
https://www.ncbi.nlm.nih.gov/pubmed/32467317
http://dx.doi.org/10.26508/lsa.202000729

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