Combined alcoholic and non-alcoholic steatohepatitis

While metabolic syndrome and alcohol consumption are the two main causes of chronic liver disease, one of the two conditions is often predominant, with the other acting as a cofactor of morbimortality. It has been shown that obesity and alcohol act synergistically to increase the risk of fibrosis pr...

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Detalles Bibliográficos
Autores principales: Ntandja Wandji, Line Carolle, Gnemmi, Viviane, Mathurin, Philippe, Louvet, Alexandre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7267467/
https://www.ncbi.nlm.nih.gov/pubmed/32514497
http://dx.doi.org/10.1016/j.jhepr.2020.100101
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author Ntandja Wandji, Line Carolle
Gnemmi, Viviane
Mathurin, Philippe
Louvet, Alexandre
author_facet Ntandja Wandji, Line Carolle
Gnemmi, Viviane
Mathurin, Philippe
Louvet, Alexandre
author_sort Ntandja Wandji, Line Carolle
collection PubMed
description While metabolic syndrome and alcohol consumption are the two main causes of chronic liver disease, one of the two conditions is often predominant, with the other acting as a cofactor of morbimortality. It has been shown that obesity and alcohol act synergistically to increase the risk of fibrosis progression, hepatic carcinogenesis and mortality, while genetic polymorphisms can strongly influence disease progression. Based on common pathogenic pathways, there are several potential targets that could be used to treat both diseases; based on the prevalence and incidence of these diseases, new therapies and clinical trials are needed urgently.
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spelling pubmed-72674672020-06-07 Combined alcoholic and non-alcoholic steatohepatitis Ntandja Wandji, Line Carolle Gnemmi, Viviane Mathurin, Philippe Louvet, Alexandre JHEP Rep Review While metabolic syndrome and alcohol consumption are the two main causes of chronic liver disease, one of the two conditions is often predominant, with the other acting as a cofactor of morbimortality. It has been shown that obesity and alcohol act synergistically to increase the risk of fibrosis progression, hepatic carcinogenesis and mortality, while genetic polymorphisms can strongly influence disease progression. Based on common pathogenic pathways, there are several potential targets that could be used to treat both diseases; based on the prevalence and incidence of these diseases, new therapies and clinical trials are needed urgently. Elsevier 2020-05-22 /pmc/articles/PMC7267467/ /pubmed/32514497 http://dx.doi.org/10.1016/j.jhepr.2020.100101 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Ntandja Wandji, Line Carolle
Gnemmi, Viviane
Mathurin, Philippe
Louvet, Alexandre
Combined alcoholic and non-alcoholic steatohepatitis
title Combined alcoholic and non-alcoholic steatohepatitis
title_full Combined alcoholic and non-alcoholic steatohepatitis
title_fullStr Combined alcoholic and non-alcoholic steatohepatitis
title_full_unstemmed Combined alcoholic and non-alcoholic steatohepatitis
title_short Combined alcoholic and non-alcoholic steatohepatitis
title_sort combined alcoholic and non-alcoholic steatohepatitis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7267467/
https://www.ncbi.nlm.nih.gov/pubmed/32514497
http://dx.doi.org/10.1016/j.jhepr.2020.100101
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