Significance of progressive liver fibrosis in pediatric liver transplants: A review of current evidence

This article reviews the current evidence and knowledge of progressive liver fibrosis after pediatric liver transplantation. This often-silent histologic finding is common in long-term survivors and may lead to allograft dysfunction in advanced stages. Surveillance through protocolized liver allogra...

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Autores principales: George, Mathew, Paci, Philippe, Taner, Timucin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2020
Materias:
Opinion Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7267692/
https://www.ncbi.nlm.nih.gov/pubmed/32536769
http://dx.doi.org/10.3748/wjg.v26.i17.1987
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author George, Mathew
Paci, Philippe
Taner, Timucin
author_facet George, Mathew
Paci, Philippe
Taner, Timucin
author_sort George, Mathew
collection PubMed
description This article reviews the current evidence and knowledge of progressive liver fibrosis after pediatric liver transplantation. This often-silent histologic finding is common in long-term survivors and may lead to allograft dysfunction in advanced stages. Surveillance through protocolized liver allograft biopsy remains the gold standard for diagnosis, and recent evidence suggests that chronic inflammation precedes fibrosis.
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spelling pubmed-72676922020-06-11 Significance of progressive liver fibrosis in pediatric liver transplants: A review of current evidence George, Mathew Paci, Philippe Taner, Timucin World J Gastroenterol Opinion Review This article reviews the current evidence and knowledge of progressive liver fibrosis after pediatric liver transplantation. This often-silent histologic finding is common in long-term survivors and may lead to allograft dysfunction in advanced stages. Surveillance through protocolized liver allograft biopsy remains the gold standard for diagnosis, and recent evidence suggests that chronic inflammation precedes fibrosis. Baishideng Publishing Group Inc 2020-05-07 2020-05-07 /pmc/articles/PMC7267692/ /pubmed/32536769 http://dx.doi.org/10.3748/wjg.v26.i17.1987 Text en ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Opinion Review
George, Mathew
Paci, Philippe
Taner, Timucin
Significance of progressive liver fibrosis in pediatric liver transplants: A review of current evidence
title Significance of progressive liver fibrosis in pediatric liver transplants: A review of current evidence
title_full Significance of progressive liver fibrosis in pediatric liver transplants: A review of current evidence
title_fullStr Significance of progressive liver fibrosis in pediatric liver transplants: A review of current evidence
title_full_unstemmed Significance of progressive liver fibrosis in pediatric liver transplants: A review of current evidence
title_short Significance of progressive liver fibrosis in pediatric liver transplants: A review of current evidence
title_sort significance of progressive liver fibrosis in pediatric liver transplants: a review of current evidence
topic Opinion Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7267692/
https://www.ncbi.nlm.nih.gov/pubmed/32536769
http://dx.doi.org/10.3748/wjg.v26.i17.1987
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