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Baricitinib counteracts metaflammation, thus protecting against diet-induced metabolic abnormalities in mice

OBJECTIVE: Recent evidence suggests the substantial pathogenic role of the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway in the development of low-grade chronic inflammatory response, known as “metaflammation,” which contributes to obesity and type 2 diabetes. In...

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Detalles Bibliográficos
Autores principales: Collotta, Debora, Hull, William, Mastrocola, Raffaella, Chiazza, Fausto, Cento, Alessia Sofia, Murphy, Catherine, Verta, Roberta, Alves, Gustavo Ferreira, Gaudioso, Giulia, Fava, Francesca, Yaqoob, Magdi, Aragno, Manuela, Tuohy, Kieran, Thiemermann, Christoph, Collino, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7267733/
https://www.ncbi.nlm.nih.gov/pubmed/32413585
http://dx.doi.org/10.1016/j.molmet.2020.101009