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Endothelial Lactate Controls Muscle Regeneration from Ischemia by Inducing M2-like Macrophage Polarization

Endothelial cell (EC)-derived signals contribute to organ regeneration, but angiocrine metabolic communication is not described. We found that EC-specific loss of the glycolytic regulator pfkfb3 reduced ischemic hindlimb revascularization and impaired muscle regeneration. This was caused by the redu...

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Detalles Bibliográficos
Autores principales:	Zhang, Jing, Muri, Jonathan, Fitzgerald, Gillian, Gorski, Tatiane, Gianni-Barrera, Roberto, Masschelein, Evi, D’Hulst, Gommaar, Gilardoni, Paola, Turiel, Guillermo, Fan, Zheng, Wang, TongTong, Planque, Mélanie, Carmeliet, Peter, Pellerin, Luc, Wolfrum, Christian, Fendt, Sarah-Maria, Banfi, Andrea, Stockmann, Christian, Soro-Arnáiz, Inés, Kopf, Manfred, De Bock, Katrien
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7267778/ https://www.ncbi.nlm.nih.gov/pubmed/32492393 http://dx.doi.org/10.1016/j.cmet.2020.05.004

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