SARS-CoV-2: diagnostic and design conundrums in the context of male factor infertility

The question of whether SARS-CoV-2 (severe acute respiratory syndrome-related coronavirus-2 [SARS-CoV-2], leading to the COVID-19 infection) can be harboured in the testes and/or semen is currently unanswered. It is essential to understand the limitations of both antibody and real-time PCR tests in...

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Detalles Bibliográficos
Autores principales: Bahadur, Gulam, Acharya, Santanu, Muneer, Asif, Huirne, Judith, Łukaszuk, Mariusz, Doreski, Pablo Alexis, Homburg, Roy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Reproductive Healthcare Ltd. Published by Elsevier Ltd. 2020
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7267791/
https://www.ncbi.nlm.nih.gov/pubmed/32565229
http://dx.doi.org/10.1016/j.rbmo.2020.05.014
Descripción
Sumario:The question of whether SARS-CoV-2 (severe acute respiratory syndrome-related coronavirus-2 [SARS-CoV-2], leading to the COVID-19 infection) can be harboured in the testes and/or semen is currently unanswered. It is essential to understand the limitations of both antibody and real-time PCR tests in interpreting SARS-CoV-2 data in relation to analyses of semen and testicular tissue without appropriate controls. This article critically analyses the evidence so far on this, and the possible implications. The limitations of diagnostic tests in both sampling and testing methodologies, their validation and their relevance in interpreting data are also highlighted.

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