SARS-CoV-2: diagnostic and design conundrums in the context of male factor infertility

The question of whether SARS-CoV-2 (severe acute respiratory syndrome-related coronavirus-2 [SARS-CoV-2], leading to the COVID-19 infection) can be harboured in the testes and/or semen is currently unanswered. It is essential to understand the limitations of both antibody and real-time PCR tests in...

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Autores principales: Bahadur, Gulam, Acharya, Santanu, Muneer, Asif, Huirne, Judith, Łukaszuk, Mariusz, Doreski, Pablo Alexis, Homburg, Roy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Reproductive Healthcare Ltd. Published by Elsevier Ltd. 2020
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7267791/
https://www.ncbi.nlm.nih.gov/pubmed/32565229
http://dx.doi.org/10.1016/j.rbmo.2020.05.014
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author Bahadur, Gulam
Acharya, Santanu
Muneer, Asif
Huirne, Judith
Łukaszuk, Mariusz
Doreski, Pablo Alexis
Homburg, Roy
author_facet Bahadur, Gulam
Acharya, Santanu
Muneer, Asif
Huirne, Judith
Łukaszuk, Mariusz
Doreski, Pablo Alexis
Homburg, Roy
author_sort Bahadur, Gulam
collection PubMed
description The question of whether SARS-CoV-2 (severe acute respiratory syndrome-related coronavirus-2 [SARS-CoV-2], leading to the COVID-19 infection) can be harboured in the testes and/or semen is currently unanswered. It is essential to understand the limitations of both antibody and real-time PCR tests in interpreting SARS-CoV-2 data in relation to analyses of semen and testicular tissue without appropriate controls. This article critically analyses the evidence so far on this, and the possible implications. The limitations of diagnostic tests in both sampling and testing methodologies, their validation and their relevance in interpreting data are also highlighted.
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spelling pubmed-72677912020-06-03 SARS-CoV-2: diagnostic and design conundrums in the context of male factor infertility Bahadur, Gulam Acharya, Santanu Muneer, Asif Huirne, Judith Łukaszuk, Mariusz Doreski, Pablo Alexis Homburg, Roy Reprod Biomed Online Commentary The question of whether SARS-CoV-2 (severe acute respiratory syndrome-related coronavirus-2 [SARS-CoV-2], leading to the COVID-19 infection) can be harboured in the testes and/or semen is currently unanswered. It is essential to understand the limitations of both antibody and real-time PCR tests in interpreting SARS-CoV-2 data in relation to analyses of semen and testicular tissue without appropriate controls. This article critically analyses the evidence so far on this, and the possible implications. The limitations of diagnostic tests in both sampling and testing methodologies, their validation and their relevance in interpreting data are also highlighted. Reproductive Healthcare Ltd. Published by Elsevier Ltd. 2020-09 2020-06-03 /pmc/articles/PMC7267791/ /pubmed/32565229 http://dx.doi.org/10.1016/j.rbmo.2020.05.014 Text en © 2020 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Commentary
Bahadur, Gulam
Acharya, Santanu
Muneer, Asif
Huirne, Judith
Łukaszuk, Mariusz
Doreski, Pablo Alexis
Homburg, Roy
SARS-CoV-2: diagnostic and design conundrums in the context of male factor infertility
title SARS-CoV-2: diagnostic and design conundrums in the context of male factor infertility
title_full SARS-CoV-2: diagnostic and design conundrums in the context of male factor infertility
title_fullStr SARS-CoV-2: diagnostic and design conundrums in the context of male factor infertility
title_full_unstemmed SARS-CoV-2: diagnostic and design conundrums in the context of male factor infertility
title_short SARS-CoV-2: diagnostic and design conundrums in the context of male factor infertility
title_sort sars-cov-2: diagnostic and design conundrums in the context of male factor infertility
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7267791/
https://www.ncbi.nlm.nih.gov/pubmed/32565229
http://dx.doi.org/10.1016/j.rbmo.2020.05.014
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