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Antidiabetic Activity of Aloe vera Leaves

This research evaluated the potential of using the methanol extract of Aloe vera (L.) Burm.f (AVM) to prevent the formation of AGEs by means of the BSA/glucose assay, BSA-methylglyoxal assay, arginine-methylglyoxal assay, fructosamine, Nɛ-(carboxymethyl) lysine (CML), thiol groups, and carbonyl prot...

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Autores principales: Muñiz-Ramirez, Alethia, Perez, Rosa M., Garcia, Efren, Garcia, Fabiola E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7267870/
https://www.ncbi.nlm.nih.gov/pubmed/32565868
http://dx.doi.org/10.1155/2020/6371201
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author Muñiz-Ramirez, Alethia
Perez, Rosa M.
Garcia, Efren
Garcia, Fabiola E.
author_facet Muñiz-Ramirez, Alethia
Perez, Rosa M.
Garcia, Efren
Garcia, Fabiola E.
author_sort Muñiz-Ramirez, Alethia
collection PubMed
description This research evaluated the potential of using the methanol extract of Aloe vera (L.) Burm.f (AVM) to prevent the formation of AGEs by means of the BSA/glucose assay, BSA-methylglyoxal assay, arginine-methylglyoxal assay, fructosamine, Nɛ-(carboxymethyl) lysine (CML), thiol groups, and carbonyl protein in vitro. The effect of AVM was also evaluated with regard to inhibiting the enzymes α-amylase, α-glucosidase, and pancreatic lipase. For this, the plant was dried, ground, and subsequently macerated with methanol. Aloe vera methanol extract (AVM) significantly decreased the formation of AGEs, as well as the formation of fructosamine, CML, and carbonyl protein. The concentration of 5 mg/ml of AVM presented the best results. AVM significantly inhibited the α-amylase and α-glucosidase enzymes. As regards the content of thiol groups, a significant increase was observed during the four weeks of the experiment. So, we can conclude that Aloe vera methanol extract decreases the formation of AGEs and may inhibit the increase in postprandial glucose, suggesting that AVM can prevent diabetes complications associated with AGE.
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spelling pubmed-72678702020-06-20 Antidiabetic Activity of Aloe vera Leaves Muñiz-Ramirez, Alethia Perez, Rosa M. Garcia, Efren Garcia, Fabiola E. Evid Based Complement Alternat Med Research Article This research evaluated the potential of using the methanol extract of Aloe vera (L.) Burm.f (AVM) to prevent the formation of AGEs by means of the BSA/glucose assay, BSA-methylglyoxal assay, arginine-methylglyoxal assay, fructosamine, Nɛ-(carboxymethyl) lysine (CML), thiol groups, and carbonyl protein in vitro. The effect of AVM was also evaluated with regard to inhibiting the enzymes α-amylase, α-glucosidase, and pancreatic lipase. For this, the plant was dried, ground, and subsequently macerated with methanol. Aloe vera methanol extract (AVM) significantly decreased the formation of AGEs, as well as the formation of fructosamine, CML, and carbonyl protein. The concentration of 5 mg/ml of AVM presented the best results. AVM significantly inhibited the α-amylase and α-glucosidase enzymes. As regards the content of thiol groups, a significant increase was observed during the four weeks of the experiment. So, we can conclude that Aloe vera methanol extract decreases the formation of AGEs and may inhibit the increase in postprandial glucose, suggesting that AVM can prevent diabetes complications associated with AGE. Hindawi 2020-05-24 /pmc/articles/PMC7267870/ /pubmed/32565868 http://dx.doi.org/10.1155/2020/6371201 Text en Copyright © 2020 Alethia Muñiz-Ramirez et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Muñiz-Ramirez, Alethia
Perez, Rosa M.
Garcia, Efren
Garcia, Fabiola E.
Antidiabetic Activity of Aloe vera Leaves
title Antidiabetic Activity of Aloe vera Leaves
title_full Antidiabetic Activity of Aloe vera Leaves
title_fullStr Antidiabetic Activity of Aloe vera Leaves
title_full_unstemmed Antidiabetic Activity of Aloe vera Leaves
title_short Antidiabetic Activity of Aloe vera Leaves
title_sort antidiabetic activity of aloe vera leaves
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7267870/
https://www.ncbi.nlm.nih.gov/pubmed/32565868
http://dx.doi.org/10.1155/2020/6371201
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