Functional Coupling between the Unfolded Protein Response and Endoplasmic Reticulum/Golgi Ca(2+)-ATPases Promotes Stress Tolerance, Cell Wall Biosynthesis, and Virulence of Aspergillus fumigatus

Many species of pathogenic fungi deploy the unfolded protein response (UPR) to expand the folding capacity of the endoplasmic reticulum (ER) in proportion to the demand for virulence-related proteins that traffic through the secretory pathway. Although Ca(2+) plays a pivotal role in ER function, the...

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Detalles Bibliográficos
Autores principales: Weichert, Martin, Guirao-Abad, José, Aimanianda, Vishukumar, Krishnan, Karthik, Grisham, Christina, Snyder, Patrick, Sheehan, Alex, Abbu, Ruthvik R., Liu, Hong, Filler, Scott G., Gruenstein, Eric I., Latgé, Jean-Paul, Askew, David S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7267887/
https://www.ncbi.nlm.nih.gov/pubmed/32487759
http://dx.doi.org/10.1128/mBio.01060-20

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