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Cerebellar function in children with and without dyslexia during single word processing
The cerebellar deficit hypothesis of dyslexia posits that dysfunction of the cerebellum is the underlying cause for reading difficulties observed in this common learning disability. The present study used functional magnetic resonance imaging (fMRI) and a single word processing task to test for diff...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7267899/ https://www.ncbi.nlm.nih.gov/pubmed/31597004 http://dx.doi.org/10.1002/hbm.24792 |
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author | Ashburn, Sikoya M. Flowers, D. Lynn Napoliello, Eileen M. Eden, Guinevere F. |
author_facet | Ashburn, Sikoya M. Flowers, D. Lynn Napoliello, Eileen M. Eden, Guinevere F. |
author_sort | Ashburn, Sikoya M. |
collection | PubMed |
description | The cerebellar deficit hypothesis of dyslexia posits that dysfunction of the cerebellum is the underlying cause for reading difficulties observed in this common learning disability. The present study used functional magnetic resonance imaging (fMRI) and a single word processing task to test for differences in activity and connectivity in children with (n = 23) and without (n = 23) dyslexia. We found cerebellar activity in the control group when word processing was compared to fixation, but not when it was compared to the active baseline task designed to reveal activity specific to reading. In the group with dyslexia there was no cerebellar activity for either contrasts and there were no differences when they were compared to children without dyslexia. Turning to functional connectivity (FC) in the controls, background FC (i.e., not specific to reading) was predominately found between the cerebellum and the occipitaltemporal cortex. In the group with dyslexia, there was background FC between the cerebellum and several cortical regions. When comparing the two groups, they differed in background FC in connections between the seed region right crus I and three left‐hemisphere perisylvian target regions. However, there was no task‐specific FC for word processing in either group and no between‐group differences. Together the results do not support the theory that the cerebellum is affected functionally during reading in children with dyslexia. |
format | Online Article Text |
id | pubmed-7267899 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-72678992020-06-12 Cerebellar function in children with and without dyslexia during single word processing Ashburn, Sikoya M. Flowers, D. Lynn Napoliello, Eileen M. Eden, Guinevere F. Hum Brain Mapp Research Articles The cerebellar deficit hypothesis of dyslexia posits that dysfunction of the cerebellum is the underlying cause for reading difficulties observed in this common learning disability. The present study used functional magnetic resonance imaging (fMRI) and a single word processing task to test for differences in activity and connectivity in children with (n = 23) and without (n = 23) dyslexia. We found cerebellar activity in the control group when word processing was compared to fixation, but not when it was compared to the active baseline task designed to reveal activity specific to reading. In the group with dyslexia there was no cerebellar activity for either contrasts and there were no differences when they were compared to children without dyslexia. Turning to functional connectivity (FC) in the controls, background FC (i.e., not specific to reading) was predominately found between the cerebellum and the occipitaltemporal cortex. In the group with dyslexia, there was background FC between the cerebellum and several cortical regions. When comparing the two groups, they differed in background FC in connections between the seed region right crus I and three left‐hemisphere perisylvian target regions. However, there was no task‐specific FC for word processing in either group and no between‐group differences. Together the results do not support the theory that the cerebellum is affected functionally during reading in children with dyslexia. John Wiley & Sons, Inc. 2019-10-09 /pmc/articles/PMC7267899/ /pubmed/31597004 http://dx.doi.org/10.1002/hbm.24792 Text en © 2019 The Authors. Human Brain Mapping published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Ashburn, Sikoya M. Flowers, D. Lynn Napoliello, Eileen M. Eden, Guinevere F. Cerebellar function in children with and without dyslexia during single word processing |
title | Cerebellar function in children with and without dyslexia during single word processing |
title_full | Cerebellar function in children with and without dyslexia during single word processing |
title_fullStr | Cerebellar function in children with and without dyslexia during single word processing |
title_full_unstemmed | Cerebellar function in children with and without dyslexia during single word processing |
title_short | Cerebellar function in children with and without dyslexia during single word processing |
title_sort | cerebellar function in children with and without dyslexia during single word processing |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7267899/ https://www.ncbi.nlm.nih.gov/pubmed/31597004 http://dx.doi.org/10.1002/hbm.24792 |
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