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Reliability of a functional magnetic resonance imaging task of emotional conflict in healthy participants

Task‐based functional neuroimaging methods are increasingly being used to identify biomarkers of treatment response in psychiatric disorders. To facilitate meaningful interpretation of neural correlates of tasks and their potential changes with treatment over time, understanding the reliability of t...

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Autores principales: Hassel, Stefanie, Sharma, Gulshan B., Alders, Gésine L., Davis, Andrew D., Arnott, Stephen R., Frey, Benicio N., Hall, Geoffrey B., Harris, Jacqueline K., Lam, Raymond W., Milev, Roumen, Müller, Daniel J., Rotzinger, Susan, Zamyadi, Mojdeh, Kennedy, Sidney H., Strother, Stephen C., MacQueen, Glenda M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7267954/
https://www.ncbi.nlm.nih.gov/pubmed/31794150
http://dx.doi.org/10.1002/hbm.24883
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author Hassel, Stefanie
Sharma, Gulshan B.
Alders, Gésine L.
Davis, Andrew D.
Arnott, Stephen R.
Frey, Benicio N.
Hall, Geoffrey B.
Harris, Jacqueline K.
Lam, Raymond W.
Milev, Roumen
Müller, Daniel J.
Rotzinger, Susan
Zamyadi, Mojdeh
Kennedy, Sidney H.
Strother, Stephen C.
MacQueen, Glenda M.
author_facet Hassel, Stefanie
Sharma, Gulshan B.
Alders, Gésine L.
Davis, Andrew D.
Arnott, Stephen R.
Frey, Benicio N.
Hall, Geoffrey B.
Harris, Jacqueline K.
Lam, Raymond W.
Milev, Roumen
Müller, Daniel J.
Rotzinger, Susan
Zamyadi, Mojdeh
Kennedy, Sidney H.
Strother, Stephen C.
MacQueen, Glenda M.
author_sort Hassel, Stefanie
collection PubMed
description Task‐based functional neuroimaging methods are increasingly being used to identify biomarkers of treatment response in psychiatric disorders. To facilitate meaningful interpretation of neural correlates of tasks and their potential changes with treatment over time, understanding the reliability of the blood‐oxygen‐level dependent (BOLD) signal of such tasks is essential. We assessed test–retest reliability of an emotional conflict task in healthy participants collected as part of the Canadian Biomarker Integration Network in Depression. Data for 36 participants, scanned at three time points (weeks 0, 2, and 8) were analyzed, and intra‐class correlation coefficients (ICC) were used to quantify reliability. We observed moderate reliability (median ICC values between 0.5 and 0.6), within occipital, parietal, and temporal regions, specifically for conditions of lower cognitive complexity, that is, face, congruent or incongruent trials. For these conditions, activation was also observed within frontal and sub‐cortical regions, however, their reliability was poor (median ICC < 0.2). Clinically relevant prognostic markers based on task‐based fMRI require high predictive accuracy at an individual level. For this to be achieved, reliability of BOLD responses needs to be high. We have shown that reliability of the BOLD response to an emotional conflict task in healthy individuals is moderate. Implications of these findings to further inform studies of treatment effects and biomarker discovery are discussed.
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spelling pubmed-72679542020-06-12 Reliability of a functional magnetic resonance imaging task of emotional conflict in healthy participants Hassel, Stefanie Sharma, Gulshan B. Alders, Gésine L. Davis, Andrew D. Arnott, Stephen R. Frey, Benicio N. Hall, Geoffrey B. Harris, Jacqueline K. Lam, Raymond W. Milev, Roumen Müller, Daniel J. Rotzinger, Susan Zamyadi, Mojdeh Kennedy, Sidney H. Strother, Stephen C. MacQueen, Glenda M. Hum Brain Mapp Research Articles Task‐based functional neuroimaging methods are increasingly being used to identify biomarkers of treatment response in psychiatric disorders. To facilitate meaningful interpretation of neural correlates of tasks and their potential changes with treatment over time, understanding the reliability of the blood‐oxygen‐level dependent (BOLD) signal of such tasks is essential. We assessed test–retest reliability of an emotional conflict task in healthy participants collected as part of the Canadian Biomarker Integration Network in Depression. Data for 36 participants, scanned at three time points (weeks 0, 2, and 8) were analyzed, and intra‐class correlation coefficients (ICC) were used to quantify reliability. We observed moderate reliability (median ICC values between 0.5 and 0.6), within occipital, parietal, and temporal regions, specifically for conditions of lower cognitive complexity, that is, face, congruent or incongruent trials. For these conditions, activation was also observed within frontal and sub‐cortical regions, however, their reliability was poor (median ICC < 0.2). Clinically relevant prognostic markers based on task‐based fMRI require high predictive accuracy at an individual level. For this to be achieved, reliability of BOLD responses needs to be high. We have shown that reliability of the BOLD response to an emotional conflict task in healthy individuals is moderate. Implications of these findings to further inform studies of treatment effects and biomarker discovery are discussed. John Wiley & Sons, Inc. 2019-12-03 /pmc/articles/PMC7267954/ /pubmed/31794150 http://dx.doi.org/10.1002/hbm.24883 Text en © 2019 The Authors. Human Brain Mapping published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Hassel, Stefanie
Sharma, Gulshan B.
Alders, Gésine L.
Davis, Andrew D.
Arnott, Stephen R.
Frey, Benicio N.
Hall, Geoffrey B.
Harris, Jacqueline K.
Lam, Raymond W.
Milev, Roumen
Müller, Daniel J.
Rotzinger, Susan
Zamyadi, Mojdeh
Kennedy, Sidney H.
Strother, Stephen C.
MacQueen, Glenda M.
Reliability of a functional magnetic resonance imaging task of emotional conflict in healthy participants
title Reliability of a functional magnetic resonance imaging task of emotional conflict in healthy participants
title_full Reliability of a functional magnetic resonance imaging task of emotional conflict in healthy participants
title_fullStr Reliability of a functional magnetic resonance imaging task of emotional conflict in healthy participants
title_full_unstemmed Reliability of a functional magnetic resonance imaging task of emotional conflict in healthy participants
title_short Reliability of a functional magnetic resonance imaging task of emotional conflict in healthy participants
title_sort reliability of a functional magnetic resonance imaging task of emotional conflict in healthy participants
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7267954/
https://www.ncbi.nlm.nih.gov/pubmed/31794150
http://dx.doi.org/10.1002/hbm.24883
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