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Impaired interactions among white‐matter functional networks in antipsychotic‐naive first‐episode schizophrenia

Schizophrenia has been conceptualized as a disorder arising from structurally pathological alterations to white‐matter fibers in the brain. However, few studies have focused on white‐matter functional changes in schizophrenia. Considering that converging evidence suggests that white‐matter resting s...

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Autores principales: Fan, Yun‐Shuang, Li, Zehan, Duan, Xujun, Xiao, Jinming, Guo, Xiaonan, Han, Shaoqiang, Guo, Jing, Yang, Siqi, Li, Jiao, Cui, Qian, Liao, Wei, Chen, Huafu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7267955/
https://www.ncbi.nlm.nih.gov/pubmed/31571346
http://dx.doi.org/10.1002/hbm.24801
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author Fan, Yun‐Shuang
Li, Zehan
Duan, Xujun
Xiao, Jinming
Guo, Xiaonan
Han, Shaoqiang
Guo, Jing
Yang, Siqi
Li, Jiao
Cui, Qian
Liao, Wei
Chen, Huafu
author_facet Fan, Yun‐Shuang
Li, Zehan
Duan, Xujun
Xiao, Jinming
Guo, Xiaonan
Han, Shaoqiang
Guo, Jing
Yang, Siqi
Li, Jiao
Cui, Qian
Liao, Wei
Chen, Huafu
author_sort Fan, Yun‐Shuang
collection PubMed
description Schizophrenia has been conceptualized as a disorder arising from structurally pathological alterations to white‐matter fibers in the brain. However, few studies have focused on white‐matter functional changes in schizophrenia. Considering that converging evidence suggests that white‐matter resting state functional MRI (rsfMRI) signals can effectively depict neuronal activity and psychopathological status, this study examined white‐matter network‐level interactions in antipsychotic‐naive first‐episode schizophrenia (FES) to facilitate the interpretation of the psychiatric pathological mechanisms in schizophrenia. We recruited 42 FES patients (FESs) and 38 healthy controls (HCs), all of whom underwent rsfMRI. We identified 11 white‐matter functional networks, which could be further classified into deep, middle, and superficial layers of networks. We then examined network‐level interactions among these 11 white‐matter functional networks using coefficient Granger causality analysis. We employed group comparisons on the influences among 11 networks using network‐based statistic. Excitatory influences from the middle superior corona radiate network to the superficial orbitofrontal and deep networks were disrupted in FESs compared with HCs. Additionally, an extra failure of suppression within superficial networks (including the frontoparietal network, temporofrontal network, and the orbitofrontal network) was observed in FESs. We additionally recruited an independent cohort (13 FESs and 13 HCs) from another center to examine the replicability of our findings across centers. Similar replication results further verified the white‐matter functional network interaction model of schizophrenia. The novel findings of impaired interactions among white‐matter functional networks in schizophrenia indicate that the pathophysiology of schizophrenia may also lie in white‐matter functional abnormalities.
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spelling pubmed-72679552020-06-12 Impaired interactions among white‐matter functional networks in antipsychotic‐naive first‐episode schizophrenia Fan, Yun‐Shuang Li, Zehan Duan, Xujun Xiao, Jinming Guo, Xiaonan Han, Shaoqiang Guo, Jing Yang, Siqi Li, Jiao Cui, Qian Liao, Wei Chen, Huafu Hum Brain Mapp Research Articles Schizophrenia has been conceptualized as a disorder arising from structurally pathological alterations to white‐matter fibers in the brain. However, few studies have focused on white‐matter functional changes in schizophrenia. Considering that converging evidence suggests that white‐matter resting state functional MRI (rsfMRI) signals can effectively depict neuronal activity and psychopathological status, this study examined white‐matter network‐level interactions in antipsychotic‐naive first‐episode schizophrenia (FES) to facilitate the interpretation of the psychiatric pathological mechanisms in schizophrenia. We recruited 42 FES patients (FESs) and 38 healthy controls (HCs), all of whom underwent rsfMRI. We identified 11 white‐matter functional networks, which could be further classified into deep, middle, and superficial layers of networks. We then examined network‐level interactions among these 11 white‐matter functional networks using coefficient Granger causality analysis. We employed group comparisons on the influences among 11 networks using network‐based statistic. Excitatory influences from the middle superior corona radiate network to the superficial orbitofrontal and deep networks were disrupted in FESs compared with HCs. Additionally, an extra failure of suppression within superficial networks (including the frontoparietal network, temporofrontal network, and the orbitofrontal network) was observed in FESs. We additionally recruited an independent cohort (13 FESs and 13 HCs) from another center to examine the replicability of our findings across centers. Similar replication results further verified the white‐matter functional network interaction model of schizophrenia. The novel findings of impaired interactions among white‐matter functional networks in schizophrenia indicate that the pathophysiology of schizophrenia may also lie in white‐matter functional abnormalities. John Wiley & Sons, Inc. 2019-10-01 /pmc/articles/PMC7267955/ /pubmed/31571346 http://dx.doi.org/10.1002/hbm.24801 Text en © 2019 The Authors. Human Brain Mapping published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Fan, Yun‐Shuang
Li, Zehan
Duan, Xujun
Xiao, Jinming
Guo, Xiaonan
Han, Shaoqiang
Guo, Jing
Yang, Siqi
Li, Jiao
Cui, Qian
Liao, Wei
Chen, Huafu
Impaired interactions among white‐matter functional networks in antipsychotic‐naive first‐episode schizophrenia
title Impaired interactions among white‐matter functional networks in antipsychotic‐naive first‐episode schizophrenia
title_full Impaired interactions among white‐matter functional networks in antipsychotic‐naive first‐episode schizophrenia
title_fullStr Impaired interactions among white‐matter functional networks in antipsychotic‐naive first‐episode schizophrenia
title_full_unstemmed Impaired interactions among white‐matter functional networks in antipsychotic‐naive first‐episode schizophrenia
title_short Impaired interactions among white‐matter functional networks in antipsychotic‐naive first‐episode schizophrenia
title_sort impaired interactions among white‐matter functional networks in antipsychotic‐naive first‐episode schizophrenia
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7267955/
https://www.ncbi.nlm.nih.gov/pubmed/31571346
http://dx.doi.org/10.1002/hbm.24801
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